Physiol Rev Fuel your research with LabChart
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Physiol. Rev. 76: 719-766, 1996;
0031-9333/96 $15.00
This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Lindemann, B.
Right arrow Search for Related Content
PubMed
Right arrow Articles by Lindemann, B.

Physiological Reviews, Vol 76, 719-766, Copyright © 1996 by American Physiological Society

JOURNAL ARTICLE

Taste reception

B. Lindemann
Fachrichtung Physiologie, Universitat des Saarlandes, Homburg/Saar, Germany.

Recent research on cellular mechanisms of peripheral taste has defined transduction pathways involving membrane receptors, G proteins, second messengers, and ion channels. Receptors for organic tastants received much attention, because they provide the specificity of a response. Their future cloning will constitute a major advance. Taste transduction typically utilizes two or more pathways in parallel. For instance, sweet-sensitive taste cells of the rat appear to respond to sucrose with activation of adenylyl cyclase, followed by adenosine 3',5'-cyclic monophosphate (cAMP)-dependent membrane events and Ca2+ uptake. The same cells respond differently to some artificial sweeteners, i.e., with activation of phospholipase C (PLC) followed by inositol 1,4,5-trisphosphate (IP3)-dependent Ca2+ release from intracellular stores. Some bitter tastants block K+ channels or initiate the cascade receptor G1 protein, PLC, IP3, and Ca2+ release or the cascade receptor alpha-gustducin, phosphodiesterase (PDE), cAMP decrease, and opening of cAMP-blocked channels. Membrane-permeant bitter tastants may elicit a cellular response by interacting with G protein, PLC, or PDE of the above cascades. Salt taste is initiated by current flowing into the taste cell through cation channels located in the apical membrane, even though basolateral channels may also contribute (following salt diffusion through paracellular pathways). In rodents, the Na+-specific component of salt taste is typically mediated by apical amiloride-sensitive Na+ channels, but less specific and not amiloride-sensitive taste components exist in addition. Sour taste may in part be mediated by amiloride-sensitive Na+ channels conducting protons, but other mechanisms certainly contribute. Thus the transduction of taste cells generally comprises parallel pathways. Furthermore, the transduction pathways vary with the location of taste buds on the tongue and, of course, across species of animals. To identify these pathways, to understand how they are controlled and why they evolved to this complexity are major goals of present research.


This article has been cited by other articles:


Home page
 Chem SensesHome page
K. Okuda-Akabane, H. Fukami, and Y. Kitada
Mechanism of Enhancement of the Responses of the Frog Glossopharyngeal Nerve to Electrolytes by Enhancers
Chem Senses, July 1, 2008; 33(6): 523 - 530.
[Abstract] [Full Text] [PDF]

Home page
 Chem SensesHome page
F. Merigo, D. Benati, M. Galie, C. Crescimanno, F. Osculati, and A. Sbarbati
Immunohistochemical Localization of Cystic Fibrosis Transmembrane Regulator and Clara Cell Secretory Protein in Taste Receptor Cells of Rat Circumvallate Papillae
Chem Senses, March 1, 2008; 33(3): 231 - 241.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
A. Bigiani and V. Cuoghi
Localization of Amiloride-Sensitive Sodium Current and Voltage-Gated Calcium Currents in Rat Fungiform Taste Cells
J Neurophysiol, October 1, 2007; 98(4): 2483 - 2487.
[Abstract] [Full Text] [PDF]

Home page
 Chem SensesHome page
K. J. Watson, I. Kim, A. F. Baquero, C. A. Burks, L. Liu, and T. A. Gilbertson
Expression of Aquaporin Water Channels in Rat Taste Buds
Chem Senses, June 1, 2007; 32(5): 411 - 421.
[Abstract] [Full Text] [PDF]

Home page
 Chem SensesHome page
L. Leow, M-L Huckabee, S Sharma, and T. Tooley
The Influence of Taste on Swallowing Apnea, Oral Preparation Time, and Duration and Amplitude of Submental Muscle Contraction
Chem Senses, February 1, 2007; 32(2): 119 - 128.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
R. Yoshida, N. Shigemura, K. Sanematsu, K. Yasumatsu, S. Ishizuka, and Y. Ninomiya
Taste Responsiveness of Fungiform Taste Cells With Action Potentials
J Neurophysiol, December 1, 2006; 96(6): 3088 - 3095.
[Abstract] [Full Text] [PDF]

Home page
 J ANIM SCIHome page
A. S. Grout, D. M. Veira, D. M. Weary, M. A. G. von Keyserlingk, and D. Fraser
Differential effects of sodium and magnesium sulfate on water consumption by beef cattle
J Anim Sci, May 1, 2006; 84(5): 1252 - 1258.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Cell Physiol.Home page
L. Liu, D. R. Hansen, I. Kim, and T. A. Gilbertson
Expression and characterization of delayed rectifying K+ channels in anterior rat taste buds
Am J Physiol Cell Physiol, October 1, 2005; 289(4): C868 - C880.
[Abstract] [Full Text] [PDF]

Home page
 Chem SensesHome page
H. Miura, H. Kato, Y. Kusakabe, Y. Ninomiya, and A. Hino
Temporal changes in NCAM immunoreactivity during taste cell differentiation and cell lineage relationships in taste buds
Chem Senses, May 1, 2005; 30(4): 367 - 375.
[Abstract] [Full Text] [PDF]

Home page
 Chem SensesHome page
K.-M. Chung, S.-B. Lee, R. Heur, Y.-K. Cho, C.-H. Lee, H.-Y. Jung, S.-H. Chung, S.-P. Lee, and K.-N. Kim
Glutamate-induced Cobalt Uptake Elicited by Kainate Receptors in Rat Taste Bud Cells
Chem Senses, February 1, 2005; 30(2): 137 - 143.
[Abstract] [Full Text] [PDF]

Home page
 Chem SensesHome page
H. Miura, H. Kato, Y. Kusakabe, M. Tagami, J. Miura-Ohnuma, T. Ookura, Y. Shindo, Y. Ninomiya, and A. Hino
Shh Signaling and Regulatory Gene Expression in Mouse Taste Buds
Chem Senses, January 1, 2005; 30(suppl_1): i50 - i51.
[Full Text] [PDF]

Home page
 Chem SensesHome page
T. Sato, Y. Okada, and K. Toda
Analysis of Slow Hyperpolarizing Potentials in Frog Taste Cells Induced by Glossopharyngeal Nerve Stimulation
Chem Senses, October 1, 2004; 29(8): 651 - 657.
[Abstract] [Full Text] [PDF]

Home page
 Chem SensesHome page
B. R. Heyer, C. C. Taylor-Burds, J. D. Mitzelfelt, and E. R. Delay
Monosodium Glutamate and Sweet Taste: Discrimination between the Tastes of Sweet Stimuli and Glutamate in Rats
Chem Senses, October 1, 2004; 29(8): 721 - 729.
[Abstract] [Full Text] [PDF]

Home page
 Chem SensesHome page
T. Suwabe and Y. Kitada
Voltage-gated Inward Currents of Morphologically Identified Cells of the Frog Taste Disc
Chem Senses, January 1, 2004; 29(1): 61 - 73.
[Abstract] [Full Text] [PDF]

Home page
 Chem SensesHome page
V. Ghiaroni, F. Fieni, P. Pietra, and A. Bigiani
Electrophysiological Heterogeneity in a Functional Subset of Mouse Taste Cells during Postnatal Development
Chem Senses, November 1, 2003; 28(9): 827 - 833.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
S. G. Baryshnikov, O. A. Rogachevskaja, and S. S. Kolesnikov
Calcium Signaling Mediated by P2Y Receptors in Mouse Taste Cells
J Neurophysiol, November 1, 2003; 90(5): 3283 - 3294.
[Abstract] [Full Text] [PDF]

Home page
 Chem SensesHome page
B.R. Heyer, C.C. Taylor-Burds, L.H. Tran, and E.R. Delay
Monosodium Glutamate and Sweet Taste: Generalization of Conditioned Taste Aversion between Glutamate and Sweet Stimuli in Rats
Chem Senses, September 1, 2003; 28(7): 631 - 641.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
C. H. Lemon, T. Imoto, and D. V. Smith
Differential Gurmarin Suppression of Sweet Taste Responses in Rat Solitary Nucleus Neurons
J Neurophysiol, August 1, 2003; 90(2): 911 - 923.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
K. Yasumatsu, H. Katsukawa, K. Sasamoto, and Y. Ninomiya
Recovery of Amiloride-Sensitive Neural Coding during Regeneration of the Gustatory Nerve: Behavioral-Neural Correlation of Salt Taste Discrimination
J. Neurosci., May 15, 2003; 23(10): 4362 - 4368.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
L. M. Stone, S.-S. Tan, P. P. L. Tam, and T. E. Finger
Analysis of Cell Lineage Relationships in Taste Buds
J. Neurosci., June 1, 2002; 22(11): 4522 - 4529.
[Abstract] [Full Text] [PDF]

Home page
 Chem SensesHome page
T. A. Gilbertson
Hypoosmotic Stimuli Activate a Chloride Conductance in Rat Taste Cells
Chem Senses, May 1, 2002; 27(4): 383 - 394.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
A. Bigiani, R. Cristiani, F. Fieni, V. Ghiaroni, P. Bagnoli, and P. Pietra
Postnatal Development of Membrane Excitability in Taste Cells of the Mouse Vallate Papilla
J. Neurosci., January 15, 2002; 22(2): 493 - 504.
[Abstract] [Full Text] [PDF]

Home page
 Chem SensesHome page
Y. Kitada, K. Okuda-Akabane, and Y. Mitoh
Effects of Amiloride on Gustatory Neural Responses to Salts in the Frog
Chem Senses, November 1, 2001; 26(9): 1203 - 1210.
[Abstract] [Full Text] [PDF]

Home page
 Chem SensesHome page
D. B.T. McMahon, H. Shikata, and P. A.S. Breslin
Are Human Taste Thresholds Similar on the Right and Left Sides of the Tongue?
Chem Senses, September 1, 2001; 26(7): 875 - 883.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
T. A. Gilbertson, J. D. Boughter Jr, H. Zhang, and D. V. Smith
Distribution of Gustatory Sensitivities in Rat Taste Cells: Whole-Cell Responses to Apical Chemical Stimulation
J. Neurosci., July 1, 2001; 21(13): 4931 - 4941.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
A. Bigiani
Mouse Taste Cells With Glialike Membrane Properties
J Neurophysiol, April 1, 2001; 85(4): 1552 - 1560.
[Abstract] [Full Text] [PDF]

Home page
 Chem SensesHome page
M. A. Miyoshi, K. Abe, and Y. Emori
IP3 receptor type 3 and PLC{beta}2 are co-expressed with taste receptors T1R and T2R in rat taste bud cells
Chem Senses, April 1, 2001; 26(3): 259 - 265.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Cell Physiol.Home page
W. Yan, G. Sunavala, S. Rosenzweig, M. Dasso, J. G. Brand, and A. I. Spielman
Bitter taste transduced by PLC-{beta}2-dependent rise in IP3 and {alpha}-gustducin-dependent fall in cyclic nucleotides
Am J Physiol Cell Physiol, April 1, 2001; 280(4): C742 - C751.
[Abstract] [Full Text] [PDF]

Home page
 Chem SensesHome page
T. Miyamoto, T. Miyazaki, R. Fujiyama, Y. Okada, and T. Sato
Differential Transduction Mechanisms Underlying NaCl- and KCl-induced Responses in Mouse Taste Cells
Chem Senses, January 1, 2001; 26(1): 67 - 77.
[Abstract] [Full Text] [PDF]

Home page
 Chem SensesHome page
K. M. Rankin and L. E. Marks
Chemosensory Context Effects: Role of Perceived Similarity and Neural Commonality
Chem Senses, December 1, 2000; 25(6): 747 - 759.
[Abstract] [Full Text] [PDF]

Home page
 Chem SensesHome page
Y. Kusakabe, A. Yasuoka, M. Asano-Miyoshi, K. Iwabuchi, I. Matsumoto, S. Arai, Y. Emori, and K. Abe
Comprehensive Study on G protein {alpha}-Subunits in Taste Bud Cells, with Special Reference to the Occurrence of G{alpha}i2 as a Major G{alpha} Species
Chem Senses, October 1, 2000; 25(5): 525 - 531.
[Abstract] [Full Text] [PDF]

Home page
 Chem SensesHome page
L. Ruiz-Avila, D. Ming, and R. F. Margolskee
An In Vitro Assay Useful to Determine the Potency of Several Bitter Compounds
Chem Senses, August 1, 2000; 25(4): 361 - 368.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Cell Physiol.Home page
V. Krizhanovsky, O. Agamy, and M. Naim
Sucrose-stimulated subsecond transient increase in cGMP level in rat intact circumvallate taste bud cells
Am J Physiol Cell Physiol, July 1, 2000; 279(1): C120 - C125.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Gastrointest. Liver Physiol.Home page
D. B. Katz, M. A. L. Nicolelis, and S. A. Simon
Nutrient Tasting and Signaling Mechanisms in the Gut. IV. There is more to taste than meets the tongue
Am J Physiol Gastrointest Liver Physiol, January 1, 2000; 278(1): G6 - G9.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Cell Physiol.Home page
I. Peri, H. Mamrud-Brains, S. Rodin, V. Krizhanovsky, Y. Shai, S. Nir, and M. Naim
Rapid entry of bitter and sweet tastants into liposomes and taste cells: implications for signal transduction
Am J Physiol Cell Physiol, January 1, 2000; 278(1): C17 - C25.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
D. Ming, Y. Ninomiya, and R. F. Margolskee
Blocking taste receptor activation of gustducin inhibits gustatory responses to bitter compounds
PNAS, August 17, 1999; 96(17): 9903 - 9908.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
Y. Shimizu and K. Tonosaki
Low environmental temperature modulates gustatory nerve activity and behavioral responses to NaCl in rats
Am J Physiol Regulatory Integrative Comp Physiol, August 1, 1999; 277(2): R368 - R373.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
G. T. Wong, L. Ruiz-Avila, and R. F. Margolskee
Directing Gene Expression to Gustducin-Positive Taste Receptor Cells
J. Neurosci., July 15, 1999; 19(14): 5802 - 5809.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
M. A. Barry
Recovery of Functional Response in the Nucleus of the Solitary Tract After Peripheral Gustatory Nerve Crush and Regeneration
J Neurophysiol, July 1, 1999; 82(1): 237 - 247.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
J. D. Boughter Jr., S. J. St. John, and D. V. Smith
Neural Representation of the Taste of NaCl and KCl in Gustatory Neurons of the Hamster Solitary Nucleus
J Neurophysiol, June 1, 1999; 81(6): 2636 - 2646.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
S. Rosenzweig, W. Yan, M. Dasso, and A. I. Spielman
Possible Novel Mechanism for Bitter Taste Mediated Through cGMP
J Neurophysiol, April 1, 1999; 81(4): 1661 - 1665.
[Abstract] [Full Text] [PDF]

Home page
 Chem SensesHome page
B. I. MacKinnon, M. E. Frank, T. P. Hettinger, and B. G. Rehnberg
Taste Qualities of Solutions Preferred by Hamsters
Chem Senses, February 1, 1999; 24(1): 23 - 35.
[Abstract] [Full Text] [PDF]

Home page
 J. Histochem. Cytochem.Home page
O. Kretz, P. Barbry, R. Bock, and B. Lindemann
Differential Expression of RNA and Protein of the Three Pore-forming Subunits of the Amiloride-sensitive Epithelial Sodium Channel in Taste Buds of the Rat
J. Histochem. Cytochem., January 1, 1999; 47(1): 51 - 64.
[Abstract] [Full Text]

Home page
 J. Pharmacol. Exp. Ther.Home page
S. Hu, S. Wang, J. Gibson, and T. A. Gilbertson
Inhibition of Delayed Rectifier K+ Channels by Dexfenfluramine (Redux)
J. Pharmacol. Exp. Ther., November 1, 1998; 287(2): 480 - 486.
[Abstract] [Full Text]

Home page
 J. Neurophysiol.Home page
T. Miyamoto, R. Fujiyama, Y. Okada, and T. Sato
Sour Transduction Involves Activation of NPPB-Sensitive Conductance in Mouse Taste Cells
J Neurophysiol, October 1, 1998; 80(4): 1852 - 1859.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
A. Bigiani, A. Sbarbati, F. Osculati, and P. Pietra
Electrophysiological Characterization of a Putative Supporting Cell Isolated from the Frog Taste Disk
J. Neurosci., July 15, 1998; 18(14): 5136 - 5150.
[Abstract] [Full Text] [PDF]

Home page
 J. Nutr.Home page
M. G. Tordoff and S. H. Rabusa
Calcium-Deprived Rats Avoid Sweet Compounds
J. Nutr., July 1, 1998; 128(7): 1232 - 1238.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
J. Chen, B. Dinger, and S. J. Fidone
cAMP production in rabbit carotid body: role of adenosine
J Appl Physiol, June 1, 1997; 82(6): 1771 - 1775.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
K. Kawai, K. Sugimoto, K. Nakashima, H. Miura, and Y. Ninomiya
Leptin as a modulator of sweet taste sensitivities in mice
PNAS, September 26, 2000; 97(20): 11044 - 11049.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online