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Physiol. Rev. 77: 1-20, 1997;
0031-9333/97 $15.00
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Physiological Reviews, Vol 77, 1-20, Copyright © 1997 by American Physiological Society

JOURNAL ARTICLE

Cellular and molecular neuroscience of alcoholism

I. Diamond and A. S. Gordon
Ernest Gallo Clinic and Research Center, Department of Neurology, University of California, San Francisco General Hospital, USA.

Recent advances in neuroscience have made it possible to investigate the pathophysiology of alcoholism at a cellular and molecular level. Evidence indicates that ethanol affects hormone- and neurotransmitter-activated signal transduction, leading to short-term changes in regulation of cellular functions and long-term changes in gene expression. Such changes in the brain probably underlie many of the acute and chronic neurological events in alcoholism. In addition, genetic vulnerability also plays a role in alcoholism and, perhaps, in alcoholic medical disorders.


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