Physiological Reviews, Vol. 80, No. 4, October 2000, pp. 1267-1290
Copyright ©2000 by the American Physiological Society

Proteoglycans in the Developing Brain: New Conceptual Insights for Old Proteins

Brain Research Institute, University of Zurich and Swiss Federal Institute of Technology Zurich; and Molecular Biology Laboratory, Department of Pathology, University Hospital, Zurich, Switzerland

Bandtlow, Christine E. and Dieter R. Zimmermann. Proteoglycans in the Developing Brain: New Conceptual Insights for Old Proteins. Physiol. Rev. 80: 1267-1290, 2000.Proteoglycans are a heterogeneous class of proteins bearing sulfated glycosaminoglycans. Some of the proteoglycans have distinct core protein structures, and others display similarities and thus may be grouped into families such as the syndecans, the glypicans, or the hyalectans (or lecticans). Proteoglycans can be found in almost all tissues being present in the extracellular matrix, on cellular surfaces, or in intracellular granules. In recent years, brain proteoglycans have attracted growing interest due to their highly regulated spatiotemporal expression during nervous system development and maturation. There is increasing evidence that different proteoglycans act as regulators of cell migration, axonal pathfinding, synaptogenesis, and structural plasticity. This review summarizes the most recent data on structures and functions of brain proteoglycans and focuses on new physiological concepts for their potential roles in the developing central nervous system.