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Physiol. Rev. 81: 1097-1142, 2001;
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Physiological Reviews, Vol. 81, No. 3, July 2001, pp. 1097-1142
Copyright ©2001 by the American Physiological Society

Physiological and Molecular Basis of Thyroid Hormone Action

Paul M. Yen

Molecular Regulation and Neuroendocrinology Section, Clinical Endocrinology Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland

Yen, Paul M. Physiological and Molecular Basis of Thyroid Hormone Action. Physiol. Rev. 81: 1097-1142, 2001.Thyroid hormones (THs) play critical roles in the differentiation, growth, metabolism, and physiological function of virtually all tissues. TH binds to receptors that are ligand-regulatable transcription factors belonging to the nuclear hormone receptor superfamily. Tremendous progress has been made recently in our understanding of the molecular mechanisms that underlie TH action. In this review, we present the major advances in our knowledge of the molecular mechanisms of TH action and their implications for TH action in specific tissues, resistance to thyroid hormone syndrome, and genetically engineered mouse models.




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