Physiol Rev Fuel your research with LabChart
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Physiol. Rev. 81: 971-998, 2001;
0031-9333/01 $15.00
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via ISI Web of Science (151)
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Lerma, J.
Right arrow Articles by López-García, J. C.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Lerma, J.
Right arrow Articles by López-García, J. C.

Physiological Reviews, Vol. 81, No. 3, July 2001, pp. 971-998
Copyright ©2001 by the American Physiological Society

Molecular Physiology of Kainate Receptors

Juan Lerma, Ana V. Paternain, Antonio Rodríguez-Moreno, and Juan C. López-García

Instituto Cajal, Consejo Superior de Investigaciones Científicas, Madrid, Spain

Lerma, Juan, Ana V. Paternain, Antonio Rodríguez-Moreno, and Juan C. López-García. Molecular Physiology of Kainate Receptors. Physiol. Rev. 81: 971-998, 2001.A decade ago, our understanding of the molecular properties of kainate receptors and their involvement in synaptic physiology was essentially null. A plethora of recent studies has altered this situation profoundly such that kainate receptors are now regarded as key players in the modulation of transmitter release, as important mediators of the postsynaptic actions of glutamate, and as possible targets for the development of antiepileptic and analgesic drugs. In this review, we summarize our current knowledge of the properties of kainate receptors focusing on four key issues: 1) their structural and biophysical features, 2) the important progress in their pharmacological characterization, 3) their pre- and postsynaptic mechanisms of action, and 4) their involvement in a series of physiological and pathological processes. Finally, although significant progress has been made toward the elucidation of their importance for brain function, kainate receptors remain largely an enigma and, therefore, we propose some new roads that should be explored to obtain a deeper understanding of this young, but intriguing, class of proteins.




This article has been cited by other articles:


Home page
 J. Physiol.Home page
J.-C. Platel, T. Heintz, S. Young, V. Gordon, and A. Bordey
Tonic activation of GLUK5 kainate receptors decreases neuroblast migration in whole-mounts of the subventricular zone
J. Physiol., August 15, 2008; 586(16): 3783 - 3793.
[Abstract] [Full Text] [PDF]

Home page
 J. Physiol.Home page
D. M. Kullmann and K. Lamsa
Roles of distinct glutamate receptors in induction of anti-Hebbian long-term potentiation
J. Physiol., March 15, 2008; 586(6): 1481 - 1486.
[Abstract] [Full Text] [PDF]

Home page
 J. Pharmacol. Exp. Ther.Home page
L. L. Lash, J. M. Sanders, N. Akiyama, M. Shoji, P. Postila, O. T. Pentikainen, M. Sasaki, R. Sakai, and G. T. Swanson
Novel Analogs and Stereoisomers of the Marine Toxin Neodysiherbaine with Specificity for Kainate Receptors
J. Pharmacol. Exp. Ther., February 1, 2008; 324(2): 484 - 496.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
F. Crepel and H. Daniel
Developmental Changes in Agonist-Induced Retrograde Signaling at Parallel Fiber Purkinje Cell Synapses: Role of Calcium-Induced Calcium Release
J Neurophysiol, November 1, 2007; 98(5): 2550 - 2565.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
J. R. Huxter, L. E. Zinyuk, E. v. L. Roloff, V. R. J. Clarke, N. P. Dolman, J. C. A. More, D. E. Jane, G. L. Collingridge, and R. U. Muller
Inhibition of Kainate Receptors Reduces the Frequency of Hippocampal Theta Oscillations
J. Neurosci., February 28, 2007; 27(9): 2212 - 2223.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
H. Augustin, Y. Grosjean, K. Chen, Q. Sheng, and D. E. Featherstone
Nonvesicular Release of Glutamate by Glial xCT Transporters Suppresses Glutamate Receptor Clustering In Vivo
J. Neurosci., January 3, 2007; 27(1): 111 - 123.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
F. Crepel
Developmental Changes in Retrograde Messengers Involved in Depolarization-Induced Suppression of Excitation at Parallel Fiber-Purkinje Cell Synapses in Rodents
J Neurophysiol, January 1, 2007; 97(1): 824 - 836.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
J. V. Negrete-Diaz, T. S. Sihra, J. M. Delgado-Garcia, and A. Rodriguez-Moreno
Kainate Receptor-Mediated Inhibition of Glutamate Release Involves Protein Kinase A in the Mouse Hippocampus
J Neurophysiol, October 1, 2006; 96(4): 1829 - 1837.
[Abstract] [Full Text] [PDF]

Home page
 J. Physiol.Home page
M. Miyata and K. Imoto
Different composition of glutamate receptors in corticothalamic and lemniscal synaptic responses and their roles in the firing responses of ventrobasal thalamic neurons in juvenile mice
J. Physiol., August 15, 2006; 575(1): 161 - 174.
[Abstract] [Full Text] [PDF]

Home page
 NeuroscientistHome page
M. W. Fleck
Glutamate Receptors and Endoplasmic Reticulum Quality Control: Looking beneath the Surface
Neuroscientist, June 1, 2006; 12(3): 232 - 244.
[Abstract] [PDF]

Home page
 J. Physiol.Home page
C. Gebhardt and S. G. Cull-Candy
Influence of agonist concentration on AMPA and kainate channels in CA1 pyramidal cells in rat hippocampal slices
J. Physiol., June 1, 2006; 573(2): 371 - 394.
[Abstract] [Full Text] [PDF]

Home page
 J. Physiol.Home page
A.-M. L. Fay and D. Bowie
Concanavalin-A reports agonist-induced conformational changes in the intact GluR6 kainate receptor
J. Physiol., April 1, 2006; 572(1): 201 - 213.
[Abstract] [Full Text] [PDF]

Home page
 J. Physiol.Home page
F. Maingret, S. E Lauri, T. Taira, and J. T. R Isaac
Profound regulation of neonatal CA1 rat hippocampal GABAergic transmission by functionally distinct kainate receptor populations
J. Physiol., August 15, 2005; 567(1): 131 - 142.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
F. Jaskolski, E. Normand, C. Mulle, and F. Coussen
Differential Trafficking of GluR7 Kainate Receptor Subunit Splice Variants
J. Biol. Chem., June 17, 2005; 280(24): 22968 - 22976.
[Abstract] [Full Text] [PDF]

Home page
 J. Physiol.Home page
N. Strutz-Seebohm, G. Seebohm, E. Shumilina, A. F. Mack, H.-J. Wagner, A. Lampert, F. Grahammer, G. Henke, L. Just, T. Skutella, et al.
Glucocorticoid adrenal steroids and glucocorticoid-inducible kinase isoforms in the regulation of GluR6 expression
J. Physiol., June 1, 2005; 565(2): 391 - 401.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
N. J. Bannister, T. A. Benke, J. Mellor, H. Scott, E. Gurdal, J. W. Crabtree, and J. T. R. Isaac
Developmental Changes in AMPA and Kainate Receptor-Mediated Quantal Transmission at Thalamocortical Synapses in the Barrel Cortex
J. Neurosci., May 25, 2005; 25(21): 5259 - 5271.
[Abstract] [Full Text] [PDF]

Home page
 Br J AnaesthHome page
A. Dinse, K. J. Fohr, M. Georgieff, C. Beyer, A. Bulling, and H. U. Weigt
Xenon reduces glutamate-, AMPA-, and kainate-induced membrane currents in cortical neurones
Br. J. Anaesth., April 1, 2005; 94(4): 479 - 485.
[Abstract] [Full Text] [PDF]

Home page
 J. Physiol.Home page
A. Fisahn
Kainate receptors and rhythmic activity in neuronal networks: hippocampal gamma oscillations as a tool
J. Physiol., January 1, 2005; 562(1): 65 - 72.
[Abstract] [Full Text] [PDF]

Home page
 J. Physiol.Home page
C. Marchal and C. Mulle
Postnatal maturation of mossy fibre excitatory transmission in mouse CA3 pyramidal cells: a potential role for kainate receptors
J. Physiol., November 15, 2004; 561(1): 27 - 37.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
A. Fisahn, A. Contractor, R. D. Traub, E. H. Buhl, S. F. Heinemann, and C. J. McBain
Distinct Roles for the Kainate Receptor Subunits GluR5 and GluR6 in Kainate-Induced Hippocampal Gamma Oscillations
J. Neurosci., October 27, 2004; 24(43): 9658 - 9668.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
J. K. Christensen, A. V. Paternain, S. Selak, P. K. Ahring, and J. Lerma
A Mosaic of Functional Kainate Receptors in Hippocampal Interneurons
J. Neurosci., October 13, 2004; 24(41): 8986 - 8993.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
N. Kang, L. Jiang, W. He, J. Xu, M. Nedergaard, and J. Kang
Presynaptic Inactivation of Action Potentials and Postsynaptic Inhibition of GABAA Currents Contribute to KA-Induced Disinhibition in CA1 Pyramidal Neurons
J Neurophysiol, August 1, 2004; 92(2): 873 - 882.
[Abstract] [Full Text] [PDF]

Home page
 J. Pharmacol. Exp. Ther.Home page
J. K. Christensen, T. Varming, P. K. Ahring, T. D. Jorgensen, and E. O. Nielsen
In Vitro Characterization of 5-Carboxyl-2,4-di-benzamidobenzoic Acid (NS3763), a Noncompetitive Antagonist of GLUK5 Receptors
J. Pharmacol. Exp. Ther., June 1, 2004; 309(3): 1003 - 1010.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
Z. Melyan, B. Lancaster, and H. V. Wheal
Metabotropic Regulation of Intrinsic Excitability by Synaptic Activation of Kainate Receptors
J. Neurosci., May 12, 2004; 24(19): 4530 - 4534.
[Abstract] [Full Text] [PDF]

Home page
 J Child NeurolHome page
T. A. Simeone, R. M. Sanchez, and J. M. Rho
Molecular Biology and Ontogeny of Glutamate Receptors in the Mammalian Central Nervous System
J Child Neurol, May 1, 2004; 19(5): 343 - 360.
[Abstract] [PDF]

Home page
 J. Physiol.Home page
D.-h. Youn and M. Randic
Modulation of excitatory synaptic transmission in the spinal substantia gelatinosa of mice deficient in the kainate receptor GluR5 and/or GluR6 subunit
J. Physiol., March 15, 2004; 555(3): 683 - 698.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
F. Jaskolski, F. Coussen, N. Nagarajan, E. Normand, C. Rosenmund, and C. Mulle
Subunit Composition and Alternative Splicing Regulate Membrane Delivery of Kainate Receptors
J. Neurosci., March 10, 2004; 24(10): 2506 - 2515.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
Y. H. Huang, M. Dykes-Hoberg, K. Tanaka, J. D. Rothstein, and D. E. Bergles
Climbing Fiber Activation of EAAT4 Transporters and Kainate Receptors in Cerebellar Purkinje Cells
J. Neurosci., January 7, 2004; 24(1): 103 - 111.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
N. Strutz-Seebohm, M. Werner, D. M. Madsen, G. Seebohm, Y. Zheng, C. S. Walker, A. V. Maricq, and M. Hollmann
Functional Analysis of Caenorhabditis elegans Glutamate Receptor Subunits by Domain Transplantation
J. Biol. Chem., November 7, 2003; 278(45): 44691 - 44701.
[Abstract] [Full Text] [PDF]

Home page
 Hum Mol GenetHome page
Z. M. Cader, S. Noble-Topham, D. A. Dyment, S. S. Cherny, J. D. Brown, G. P.A. Rice, and G. C. Ebers
Significant linkage to migraine with aura on chromosome 11q24
Hum. Mol. Genet., October 1, 2003; 12(19): 2511 - 2517.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
M. Nakamura, I.-S. Jang, H. Ishibashi, S. Watanabe, and N. Akaike
Possible Roles of Kainate Receptors on GABAergic Nerve Terminals Projecting to Rat Substantia Nigra Dopaminergic Neurons
J Neurophysiol, September 1, 2003; 90(3): 1662 - 1670.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
D. S. Gryder and M. A. Rogawski
Selective Antagonism of GluR5 Kainate-Receptor-Mediated Synaptic Currents by Topiramate in Rat Basolateral Amygdala Neurons
J. Neurosci., August 6, 2003; 23(18): 7069 - 7074.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
Z. Ren, N. J. Riley, E. P. Garcia, J. M. Sanders, G. T. Swanson, and J. Marshall
Multiple Trafficking Signals Regulate Kainate Receptor KA2 Subunit Surface Expression
J. Neurosci., July 23, 2003; 23(16): 6608 - 6616.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
M. Eder, K. Becker, G. Rammes, A. Schierloh, S. C. Azad, W. Zieglgansberger, and H.-U. Dodt
Distribution and Properties of Functional Postsynaptic Kainate Receptors on Neocortical Layer V Pyramidal Neurons
J. Neurosci., July 23, 2003; 23(16): 6660 - 6670.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
M. W. Fleck, E. Cornell, and S. J. Mah
Amino-Acid Residues Involved in Glutamate Receptor 6 Kainate Receptor Gating and Desensitization
J. Neurosci., February 15, 2003; 23(4): 1219 - 1227.
[Abstract] [Full Text] [PDF]

Home page
 J. Pharmacol. Exp. Ther.Home page
T. L. Crowder, O. J. Ariwodola, and J. L. Weiner
Ethanol Antagonizes Kainate Receptor-Mediated Inhibition of Evoked GABAA Inhibitory Postsynaptic Currents in the Rat Hippocampal CA1 Region
J. Pharmacol. Exp. Ther., December 1, 2002; 303(3): 937 - 944.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
H. Kamiya, S. Ozawa, and T. Manabe
Kainate Receptor-Dependent Short-Term Plasticity of Presynaptic Ca2+ Influx at the Hippocampal Mossy Fiber Synapses
J. Neurosci., November 1, 2002; 22(21): 9237 - 9243.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Pharmacol.Home page
M.-L. He, T.-a. Koshimizu, M. Tomic', and S. S. Stojilkovic
Purinergic P2X2 Receptor Desensitization Depends on Coupling between Ectodomain and C-Terminal Domain
Mol. Pharmacol., November 1, 2002; 62(5): 1187 - 1197.
[Abstract] [Full Text] [PDF]

Home page
 Sci SignalHome page
A. Contractor and S. F. Heinemann
Glutamate Receptor Trafficking in Synaptic Plasticity
Sci. Signal., October 29, 2002; 2002(156): re14 - re14.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
G. A. Kerchner, T. J. Wilding, J. E. Huettner, and M. Zhuo
Kainate Receptor Subunits Underlying Presynaptic Regulation of Transmitter Release in the Dorsal Horn
J. Neurosci., September 15, 2002; 22(18): 8010 - 8017.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
M. Frerking and P. Ohliger-Frerking
AMPA Receptors and Kainate Receptors Encode Different Features of Afferent Activity
J. Neurosci., September 1, 2002; 22(17): 7434 - 7443.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
F. Coussen, E. Normand, C. Marchal, P. Costet, D. Choquet, M. Lambert, R.-M. Mege, and C. Mulle
Recruitment of the Kainate Receptor Subunit Glutamate Receptor 6 by Cadherin/Catenin Complexes
J. Neurosci., August 1, 2002; 22(15): 6426 - 6436.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
I. Khalilov, J. Hirsch, R. Cossart, and Y. Ben-Ari
Paradoxical Anti-Epileptic Effects of a GluR5 Agonist of Kainate Receptors
J Neurophysiol, July 1, 2002; 88(1): 523 - 527.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
P. M. Zygmunt, D. A. Andersson, and E. D. Hogestatt
Delta 9-Tetrahydrocannabinol and Cannabinol Activate Capsaicin-Sensitive Sensory Nerves via a CB1 and CB2 Cannabinoid Receptor-Independent Mechanism
J. Neurosci., June 1, 2002; 22(11): 4720 - 4727.
[Abstract] [Full Text] [PDF]

Home page
 Sci SignalHome page
C. Schmauss and J. R. Howe
RNA Editing of Neurotransmitter Receptors in the Mammalian Brain
Sci. Signal., May 21, 2002; 2002(133): pe26 - pe26.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Pathol.Home page
S Davies and D B Ramsden
Huntington's disease
Mol. Pathol., December 1, 2001; 54(6): 409 - 413.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online