| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
Physiological Reviews, Vol. 82, No. 1, January 2002, pp. 19-46; 10.1152/physrev.00020.2001.
Copyright ©2002 by the American Physiological Society
Departments of Medicine and Cell Biology/Physiology, Washington University School of Medicine, St. Louis, Missouri
Holtzman, Michael J.,
Jeffrey D. Morton,
Laurie P. Shornick,
Jeffrey W. Tyner,
Mary P. O'Sullivan,
Aurita Antao,
Mindy Lo,
Mario Castro, and
Michael J. Walter.
Immunity, Inflammation, and Remodeling in the
Airway Epithelial Barrier: Epithelial-Viral-Allergic
Paradigm. Physiol. Rev. 82: 19-46, 2002.
The concept that airway inflammation leads
to airway disease has led to a widening search for the types of
cellular and molecular interactions responsible for linking the initial
stimulus to the final abnormality in airway function. It has not yet
been possible to integrate all of this information into a single model
for the development of airway inflammation and remodeling, but a useful framework has been based on the behavior of the adaptive immune system.
In that paradigm, an exaggeration of T-helper type 2 (Th2) over Th1
responses to allergic and nonallergic stimuli leads to airway
inflammatory disease, especially asthma. In this review, we summarize
alternative evidence that the innate immune system, typified by actions
of airway epithelial cells and macrophages, may also be specially
programmed for antiviral defense and abnormally programmed in
inflammatory disease. Furthermore, this abnormality may be inducible by
paramyxoviral infection and, in the proper genetic background, may
persist indefinitely. Taken together, we propose a new model that
highlights specific interactions between epithelial, viral, and
allergic components and so better explains the basis for airway
immunity, inflammation, and remodeling in response to viral infection
and the development of long-term disease phenotypes typical of
asthma and other hypersecretory airway diseases.
This article has been cited by other articles:
|
|
 |
|
  C. G. Clement, S. E. Evans, C. M. Evans, D. Hawke, R. Kobayashi, P. R. Reynolds, S. J. Moghaddam, B. L. Scott, E. Melicoff, R. Adachi, et al. Stimulation of Lung Innate Immunity Protects against Lethal Pneumococcal Pneumonia in Mice Am. J. Respir. Crit. Care Med., June 15, 2008; 177(12): 1322 - 1330. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. L. Humlicek, L. J. Manzel, C. L. Chin, L. Shi, K. J. D. A. Excoffon, M. C. Winter, D. M. Shasby, and D. C. Look Paracellular Permeability Restricts Airway Epithelial Responses to Selectively Allow Activation by Mediators at the Basolateral Surface J. Immunol., May 15, 2007; 178(10): 6395 - 6403. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 B. Mathew, G. Y. Park, H. Cao, A. C. Azim, X. Wang, R. B. Van Breemen, R. T. Sadikot, and J. W. Christman Inhibitory {kappa}B Kinase 2 Activates Airway Epithelial Cells to Stimulate Bone Marrow Macrophages Am. J. Respir. Cell Mol. Biol., May 1, 2007; 36(5): 562 - 572. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Jaradat, C. Stapleton, S. L. Tilley, D. Dixon, C. J. Erikson, J. G. McCaskill, H. S. Kang, M. Angers, G. Liao, J. Collins, et al. Modulatory Role for Retinoid-related Orphan Receptor {alpha} in Allergen-induced Lung Inflammation Am. J. Respir. Crit. Care Med., December 15, 2006; 174(12): 1299 - 1309. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. F. Chung Intrinsic differences of the airway epithelium in childhood allergic asthma. Am. J. Respir. Crit. Care Med., November 15, 2006; 174(10): 1066 - 1067. [Full Text] [PDF]
|
|
|
|
 |
|
 P E Schwarze, J Ovrevik, M Lag, M Refsnes, P Nafstad, R B Hetland, and E Dybing Particulate matter properties and health effects: consistency of epidemiological and toxicological studies Human and Experimental Toxicology, October 1, 2006; 25(10): 559 - 579. [Abstract] [PDF]
|
|
|
|
|
|
P. D. Rennert, T. Ichimura, I. D. Sizing, V. Bailly, Z. Li, R. Rennard, P. McCoon, L. Pablo, S. Miklasz, L. Tarilonte, et al. T Cell, Ig Domain, Mucin Domain-2 Gene-Deficient Mice Reveal a Novel Mechanism for the Regulation of Th2 Immune Responses and Airway Inflammation J. Immunol., October 1, 2006; 177(7): 4311 - 4321. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 F. J. Culley, A. M. J. Pennycook, J. S. Tregoning, J. S. Dodd, G. Walzl, T. N. Wells, T. Hussell, and P. J. M. Openshaw Role of CCL5 (RANTES) in Viral Lung Disease. J. Virol., August 1, 2006; 80(16): 8151 - 8157. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. J. Holtzman, J. T. Battaile, and A. C. Patel Immunogenetic Programs for Viral Induction of Mucous Cell Metaplasia Am. J. Respir. Cell Mol. Biol., July 1, 2006; 35(1): 29 - 39. [Full Text] [PDF]
|
|
|
|
 |
|
 M. J. Holtzman, J. W. Tyner, E. Y. Kim, M. S. Lo, A. C. Patel, L. P. Shornick, E. Agapov, and Y. Zhang Acute and Chronic Airway Responses to Viral Infection: Implications for Asthma and Chronic Obstructive Pulmonary Disease Proceedings of the ATS, August 1, 2005; 2(2): 132 - 140. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. J. Walter and M. J. Holtzman A Centennial History of Research on Asthma Pathogenesis Am. J. Respir. Cell Mol. Biol., June 1, 2005; 32(6): 483 - 489. [Full Text] [PDF]
|
|
|
|
|
|
A. A. Berlin and N. W. Lukacs Treatment of Cockroach Allergen Asthma Model with Imatinib Attenuates Airway Responses Am. J. Respir. Crit. Care Med., January 1, 2005; 171(1): 35 - 39. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. P. Khalifah, R. R. Hachem, M. M. Chakinala, K. B. Schechtman, G. A. Patterson, D. P. Schuster, T. Mohanakumar, E. P. Trulock, and M. J. Walter Respiratory Viral Infections Are a Distinct Risk for Bronchiolitis Obliterans Syndrome and Death Am. J. Respir. Crit. Care Med., July 15, 2004; 170(2): 181 - 187. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Castro, S. R. Bloch, M. V. Jenkerson, S. DeMartino, D. L. Hamilos, R. B. Cochran, X. E. L. Zhang, H. Wang, J. P. Bradley, K. B. Schechtman, et al. Asthma Exacerbations after Glucocorticoid Withdrawal Reflects T Cell Recruitment to the Airway Am. J. Respir. Crit. Care Med., April 1, 2004; 169(7): 842 - 849. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. D. Russell, Q. Yan, G. Fan, A. P. Khalifah, D. K. Bishop, S. L. Brody, and M. J. Walter IL-12 p40 Homodimer-Dependent Macrophage Chemotaxis and Respiratory Viral Inflammation Are Mediated through IL-12 Receptor {beta}1 J. Immunol., December 15, 2003; 171(12): 6866 - 6874. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. G. Tuteur Sputum Peroxynitrite Inhibitory Activity Is Stimulating Chest, November 1, 2003; 124(5): 1630 - 1632. [Full Text] [PDF]
|
|
|
|
|
|
I. Hussain and J. Smith Evidence for the Transmissibility of Atopy: Hypothesis Chest, November 1, 2003; 124(5): 1968 - 1974. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. J. Holtzman Drug Development for Asthma Am. J. Respir. Cell Mol. Biol., August 1, 2003; 29(2): 163 - 171. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. P. O'Sullivan, J. W. Tyner, and M. J. Holtzman Apoptosis in the Airways: Another Balancing Act in the Epithelial Program Am. J. Respir. Cell Mol. Biol., July 1, 2003; 29(1): 3 - 7. [Full Text] [PDF]
|
|
|
|
|
|
M. A. Carey, D. R. Germolec, J. A. Bradbury, R. A. Gooch, M. P. Moorman, G. P. Flake, R. Langenbach, and D. C. Zeldin Accentuated T Helper Type 2 Airway Response after Allergen Challenge in Cyclooxygenase-1-/- but Not Cyclooxygenase-2-/- Mice Am. J. Respir. Crit. Care Med., June 1, 2003; 167(11): 1509 - 1515. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. F. Ortega-Cava, S. Ishihara, M. A. K. Rumi, K. Kawashima, N. Ishimura, H. Kazumori, J. Udagawa, Y. Kadowaki, and Y. Kinoshita Strategic Compartmentalization of Toll-Like Receptor 4 in the Mouse Gut J. Immunol., April 15, 2003; 170(8): 3977 - 3985. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. A. Boushey New and Exploratory Therapies for Asthma Chest, March 1, 2003; 123(2007): 439S - 445S. [Full Text] [PDF]
|
|
|
|
 |
|
 Y. You, E. J. Richer, T. Huang, and S. L. Brody Growth and differentiation of mouse tracheal epithelial cells: selection of a proliferative population Am J Physiol Lung Cell Mol Physiol, December 1, 2002; 283(6): L1315 - L1321. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| Visit Other APS Journals Online |
