| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
Physiological Reviews, Vol. 83, No. 2, April 2003, pp. 475-579; 10.1152/physrev.00028.2002.
Copyright ©2003 by the American Physiological Society
Department of Molecular Biophysics and Physiology, Rush Presbyterian St. Luke's Medical Center, Chicago, Illinois
Decoursey, Thomas E.
Voltage-Gated Proton Channels and Other Proton Transfer
Pathways. Physiol. Rev. 83: 475-579, 2003.
Proton channels exist in a wide
variety of membrane proteins where they transport protons rapidly and
efficiently. Usually the proton pathway is formed mainly by water
molecules present in the protein, but its function is regulated by
titratable groups on critical amino acid residues in the pathway. All
proton channels conduct protons by a hydrogen-bonded chain
mechanism in which the proton hops from one water or titratable group
to the next. Voltage-gated proton channels represent a specific
subset of proton channels that have voltage- and time-dependent
gating like other ion channels. However, they differ from most ion
channels in their extraordinarily high selectivity, tiny conductance,
strong temperature and deuterium isotope effects on conductance and
gating kinetics, and insensitivity to block by steric occlusion. Gating
of H+ channels is regulated tightly by pH and voltage,
ensuring that they open only when the electrochemical gradient is
outward. Thus they function to extrude acid from cells. H+
channels are expressed in many cells. During the respiratory burst in
phagocytes, H+ current compensates for electron extrusion
by NADPH oxidase. Most evidence indicates that the H+
channel is not part of the NADPH oxidase complex, but rather is a
distinct and as yet unidentified molecule.
This article has been cited by other articles:
|
|
 |
|
  T. E. DeCoursey Voltage-gated proton channels: what's next? J. Physiol., November 15, 2008; 586(22): 5305 - 5324. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 B. Musset, D. Morgan, V. V. Cherny, D. W. MacGlashan Jr, L. L. Thomas, E. Rios, and T. E. DeCoursey A pH-stabilizing role of voltage-gated proton channels in IgE-mediated activation of human basophils PNAS, August 5, 2008; 105(31): 11020 - 11025. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. P. Koch, T. Kurokawa, Y. Okochi, M. Sasaki, Y. Okamura, and H. P. Larsson Multimeric nature of voltage-gated proton channels PNAS, July 1, 2008; 105(26): 9111 - 9116. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Thomaeus, A. Naworyta, S. L. Mowbray, and M. Widersten Removal of distal protein-water hydrogen bonds in a plant epoxide hydrolase increases catalytic turnover but decreases thermostability Protein Sci., July 1, 2008; 17(7): 1275 - 1284. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S.-Y. Lee, J. A. Letts, and R. MacKinnon Dimeric subunit stoichiometry of the human voltage-dependent proton channel Hv1 PNAS, June 3, 2008; 105(22): 7692 - 7695. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. Roth, D. Gillespie, W. Nonner, and R. E. Eisenberg Bubbles, Gating, and Anesthetics in Ion Channels Biophys. J., June 1, 2008; 94(11): 4282 - 4298. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. Numata and Y. Okada Proton Conductivity through the Human TRPM7 Channel and Its Molecular Determinants J. Biol. Chem., May 30, 2008; 283(22): 15097 - 15103. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Eder A mysterious channel: new insights into proton channel functioning raise new questions J. Physiol., May 15, 2008; 586(10): 2419 - 2420. [Full Text] [PDF]
|
|
|
|
|
|
B. Musset, V. V. Cherny, D. Morgan, Y. Okamura, I. S. Ramsey, D. E. Clapham, and T. E. DeCoursey Detailed comparison of expressed and native voltage-gated proton channel currents J. Physiol., May 15, 2008; 586(10): 2477 - 2486. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. C. Certal, R. B. Almeida, L. M. Carvalho, E. Wong, N. Moreno, E. Michard, J. Carneiro, J. Rodriguez-Leon, H.-M. Wu, A. Y. Cheung, et al. Exclusion of a Proton ATPase from the Apical Membrane Is Associated with Cell Polarity and Tip Growth in Nicotiana tabacum Pollen Tubes PLANT CELL, March 1, 2008; 20(3): 614 - 634. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. Zifarelli, P. Soliani, and M. Pusch Buffered Diffusion around a Spherical Proton Pumping Cell: A Theoretical Analysis Biophys. J., January 1, 2008; 94(1): 53 - 62. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Chen, Y. Wu, and G. A. Voth Proton Transport Behavior through the Influenza A M2 Channel: Insights from Molecular Simulation Biophys. J., November 15, 2007; 93(10): 3470 - 3479. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Narayan, D. L. Wyatt, D. S. Crumrine, and S. Cukierman Proton Transfer in Water Wires in Proteins: Modulation by Local Constraint and Polarity in Gramicidin A Channels Biophys. J., September 1, 2007; 93(5): 1571 - 1579. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. Essin, B. Salanova, R. Kettritz, M. Sausbier, F. C. Luft, D. Kraus, E. Bohn, I. B. Autenrieth, A. Peschel, P. Ruth, et al. Large-conductance calcium-activated potassium channel activity is absent in human and mouse neutrophils and is not required for innate immunity Am J Physiol Cell Physiol, July 1, 2007; 293(1): C45 - C54. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. V. Bocharov, Y. E. Pustovalova, K. V. Pavlov, P. E. Volynsky, M. V. Goncharuk, Y. S. Ermolyuk, D. V. Karpunin, A. A. Schulga, M. P. Kirpichnikov, R. G. Efremov, et al. Unique Dimeric Structure of BNip3 Transmembrane Domain Suggests Membrane Permeabilization as a Cell Death Trigger J. Biol. Chem., June 1, 2007; 282(22): 16256 - 16266. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. G. Jonz and S. Barnes Proton modulation of ion channels in isolated horizontal cells of the goldfish retina J. Physiol., June 1, 2007; 581(2): 529 - 541. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. J. Naftalin, N. Green, and P. Cunningham Lactose Permease H+-Lactose Symporter: Mechanical Switch or Brownian Ratchet? Biophys. J., May 15, 2007; 92(10): 3474 - 3491. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. Lamoureux, M. L. Klein, and S. Berneche A Stable Water Chain in the Hydrophobic Pore of the AmtB Ammonium Transporter Biophys. J., May 1, 2007; 92(9): L82 - L84. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. Mathias and D. Marx Structures and spectral signatures of protonated water networks in bacteriorhodopsin PNAS, April 24, 2007; 104(17): 6980 - 6985. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. R. Roscioli, L. R. McCunn, and M. A. Johnson Quantum Structure of the Intermolecular Proton Bond Science, April 13, 2007; 316(5822): 249 - 254. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Morgan, V. V. Cherny, A. Finnegan, J. Bollinger, M. H. Gelb, and T. E. DeCoursey Sustained activation of proton channels and NADPH oxidase in human eosinophils and murine granulocytes requires PKC but not cPLA2{alpha} activity J. Physiol., March 1, 2007; 579(2): 327 - 344. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. Bedard and K.-H. Krause The NOX Family of ROS-Generating NADPH Oxidases: Physiology and Pathophysiology Physiol Rev, January 1, 2007; 87(1): 245 - 313. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Chen, B. Ilan, Y. Wu, F. Zhu, K. Schulten, and G. A. Voth Charge Delocalization in Proton Channels, I: The Aquaporin Channels and Proton Blockage Biophys. J., January 1, 2007; 92(1): 46 - 60. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Wu, B. Ilan, and G. A. Voth Charge Delocalization in Proton Channels, II: The Synthetic LS2 Channel and Proton Selectivity Biophys. J., January 1, 2007; 92(1): 61 - 69. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 O. M. Woodward and A. O. D. Willows Dopamine modulation of Ca2+ dependent Cl- current regulates ciliary beat frequency controlling locomotion in Tritonia diomedea J. Exp. Biol., July 15, 2006; 209(14): 2749 - 2764. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. K. Femling, V. V. Cherny, D. Morgan, B. Rada, A. P. Davis, G. Czirjak, P. Enyedi, S. K. England, J. G. Moreland, E. Ligeti, et al. The Antibacterial Activity of Human Neutrophils and Eosinophils Requires Proton Channels but Not BK Channels J. Gen. Physiol., May 30, 2006; 127(6): 659 - 672. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Sasaki, M. Takagi, and Y. Okamura A Voltage Sensor-Domain Protein Is a Voltage-Gated Proton Channel Science, April 28, 2006; 312(5773): 589 - 592. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. A. Soyombo, S. Tjon-Kon-Sang, Y. Rbaibi, E. Bashllari, J. Bisceglia, S. Muallem, and K. Kiselyov TRP-ML1 Regulates Lysosomal pH and Acidic Lysosomal Lipid Hydrolytic Activity J. Biol. Chem., March 17, 2006; 281(11): 7294 - 7301. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Angelow, K.-J. Kim, and A. S. L. Yu Claudin-8 modulates paracellular permeability to acidic and basic ions in MDCK II cells J. Physiol., February 15, 2006; 571(1): 15 - 26. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. Leiderman, D. Huppert, and N. Agmon Transition in the Temperature-Dependence of GFP Fluorescence: From Proton Wires to Proton Exit Biophys. J., February 1, 2006; 90(3): 1009 - 1018. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 N. Li, G. Zhang, F.-X. Yi, A.-P. Zou, and P.-L. Li Activation of NAD(P)H oxidase by outward movements of H+ ions in renal medullary thick ascending limb of Henle Am J Physiol Renal Physiol, November 1, 2005; 289(5): F1048 - F1056. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
O. F. Mohammed, D. Pines, J. Dreyer, E. Pines, and E. T. J. Nibbering Sequential Proton Transfer Through Water Bridges in Acid-Base Reactions Science, October 7, 2005; 310(5745): 83 - 86. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. J. Klebanoff Myeloperoxidase: friend and foe J. Leukoc. Biol., May 1, 2005; 77(5): 598 - 625. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. L. Tepper and G. A. Voth Protons May Leak through Pure Lipid Bilayers via a Concerted Mechanism Biophys. J., May 1, 2005; 88(5): 3095 - 3108. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. Agmon Proton Pathways in Green Fluorescence Protein Biophys. J., April 1, 2005; 88(4): 2452 - 2461. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. A Fraser, C. E Middlebrook, J. A Usher-Smith, C. J Schwiening, and C. L.-H Huang The effect of intracellular acidification on the relationship between cell volume and membrane potential in amphibian skeletal muscle J. Physiol., March 15, 2005; 563(3): 745 - 764. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. Brunaldi, M. A. Miranda, F. Abdulkader, R. Curi, and J. Procopio Fatty acid flip-flop and proton transport determined by short-circuit current in planar bilayers J. Lipid Res., February 1, 2005; 46(2): 245 - 251. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. Murphy, V. V. Cherny, D. Morgan, and T. E. DeCoursey Voltage-gated proton channels help regulate pHi in rat alveolar epithelium Am J Physiol Lung Cell Mol Physiol, February 1, 2005; 288(2): L398 - L408. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 B. K. Rada, M. Geiszt, K. Kaldi, C. Timar, and E. Ligeti Dual role of phagocytic NADPH oxidase in bacterial killing Blood, November 1, 2004; 104(9): 2947 - 2953. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Braun-Sand, M. Strajbl, and A. Warshel Studies of Proton Translocations in Biological Systems: Simulating Proton Transport in Carbonic Anhydrase by EVB-Based Models Biophys. J., October 1, 2004; 87(4): 2221 - 2239. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. J. Kemp and K.-J. Kim Spectrum of ion channels in alveolar epithelial cells: implications for alveolar fluid balance Am J Physiol Lung Cell Mol Physiol, September 1, 2004; 287(3): L460 - L464. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
V. Vijayvergiya, R. Wilson, A. Chorak, P. F. Gao, T. A. Cross, and D. D. Busath Proton Conductance of Influenza Virus M2 Protein in Planar Lipid Bilayers Biophys. J., September 1, 2004; 87(3): 1697 - 1704. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Schwarzer, T. E. Machen, B. Illek, and H. Fischer NADPH Oxidase-dependent Acid Production in Airway Epithelial Cells J. Biol. Chem., August 27, 2004; 279(35): 36454 - 36461. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. Hellwig, T. D. Plant, W. Janson, M. Schafer, G. Schultz, and M. Schaefer TRPV1 Acts as Proton Channel to Induce Acidification in Nociceptive Neurons J. Biol. Chem., August 13, 2004; 279(33): 34553 - 34561. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. E. DeCoursey During the Respiratory Burst, Do Phagocytes Need Proton Channels or Potassium Channels, or Both? Sci. Signal., May 18, 2004; 2004(233): pe21 - pe21. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. Eisenberg Why Can't Protons Move through Water Channels? Biophys. J., December 1, 2003; 85(6): 3427 - 3428. [Full Text] [PDF]
|
|
|
|
|
|
A. Burykin and A. Warshel What Really Prevents Proton Transport through Aquaporin? Charge Self-Energy versus Proton Wire Proposals Biophys. J., December 1, 2003; 85(6): 3696 - 3706. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. L. Petheo, A. Maturana, A. Spat, and N. Demaurex Interactions between Electron and Proton Currents in Excised Patches from Human Eosinophils J. Gen. Physiol., November 24, 2003; 122(6): 713 - 726. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. Urbankova, A. Voltchenko, P. Pohl, P. Jezek, and E. E. Pohl Transport Kinetics of Uncoupling Proteins: ANALYSIS OF UCP1 RECONSTITUTED IN PLANAR LIPID BILAYERS J. Biol. Chem., August 29, 2003; 278(35): 32497 - 32500. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. V. Gabel and H. C. Berg The speed of the flagellar rotary motor of Escherichia coli varies linearly with protonmotive force PNAS, July 22, 2003; 100(15): 8748 - 8751. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
V. V. Cherny, R. Murphy, V. Sokolov, R. A. Levis, and T. E. DeCoursey Properties of Single Voltage-gated Proton Channels in Human Eosinophils Estimated by Noise Analysis and by Direct Measurement J. Gen. Physiol., May 27, 2003; 121(6): 615 - 628. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| Visit Other APS Journals Online |
