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Physiol. Rev. 84: 623-647, 2004; doi:10.1152/physrev.00032.2003
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Mouse Models of Insulin Resistance

ANINDITA NANDI, YUKARI KITAMURA, C. RONALD KAHN and DOMENICO ACCILI

Department of Medicine, College of Physicians and Surgeons of Columbia University, New York, New York; and Joslin Diabetes Center, Harvard University Medical School, Boston, Massachusetts

Nandi, Anindita, Yukari Kitamura, C. Ronald Kahn, and Domenico Accili. Mouse Models of Insulin Resistance. Physiol Rev 84: 623–647, 2004; 10.1152/physrev.00032.2003.—Insulin resistance plays a key role in the pathogenesis of several human diseases, including diabetes, obesity, hypertension, and cardiovascular diseases. The predisposi-tion to insulin resistance results from genetic and environmental factors. The search for gene variants that predispose to insulin resistance has been thwarted by its genetically heterogeneous pathogenesis. However, using techniques of targeted mutagenesis and transgenesis in rodents, investigators have developed mouse models to test critical hypotheses on the pathogenesis of insulin resistance. Moreover, experimental crosses among mutant mice have shed light onto the polygenic nature of the interactions underlying this complex metabolic condition.

Address for reprint requests and other correspondence: D. Accili, Berrie Research Pavilion, 1150 St. Nicholas Ave., New York, NY 10032 (E-mail: da230{at}columbia.edu).




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