| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
Centre for Cardiovascular Biology and Medicine, King's College London, New Hunt's House, London, United Kingdom
This review summarizes the receptor-mediated vascular activities of calcitonin gene-related peptide (CGRP) and the structurally related peptide adrenomedullin (AM). CGRP is a 37-amino acid neuropeptide, primarily released from sensory nerves, whilst AM is produced by stimulated vascular cells, and amylin is secreted from the pancreas. They share vasodilator activity, albeit to varying extents depending on species and tissue. In particular, CGRP has potent activity in the cerebral circulation, which is possibly relevant to the pathology of migraine, whilst vascular sources of AM contribute to dysfunction in cardiovascular disease. Both peptides exhibit potent activity in microvascular beds. All three peptides can act on a family of CGRP receptors that consist of calcitonin receptor-like receptor (CL) linked to one of three receptor activity-modifying proteins (RAMPs) that are essential for functional activity. The association of CL with RAMP1 produces a CGRP receptor, with RAMP2 an AM receptor and with RAMP3 a CGRP/AM receptor. Evidence for the selective activity of the first nonpeptide CGRP antagonist BIBN4096BS for the CGRP receptor is presented. The cardiovascular activity of these peptides in a range of species and in human clinical conditions is detailed, and potential therapeutic applications based on use of antagonists and gene targeting of agonists are discussed.
This article has been cited by other articles:
|
|
 |
|
  M. Li, Y. Wu, and K. M. Caron Haploinsufficiency for Adrenomedullin Reduces Pinopodes and Diminishes Uterine Receptivity in Mice Biol Reprod, December 1, 2008; 79(6): 1169 - 1175. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M Hennenberg, J Trebicka, T Sauerbruch, and J Heller Mechanisms of extrahepatic vasodilation in portal hypertension Gut, September 1, 2008; 57(9): 1300 - 1314. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Zulli, B. Ye, P. J. Wookey, B. F. Buxton, and D. L. Hare Calcitonin gene-related peptide inhibits angiotensin II-mediated vasoconstriction in human radial arteries: role of the Kir channel. J. Thorac. Cardiovasc. Surg., August 1, 2008; 136(2): 370 - 375. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 B. Zhong and D. H. Wang N-oleoyldopamine, a novel endogenous capsaicin-like lipid, protects the heart against ischemia-reperfusion injury via activation of TRPV1 Am J Physiol Heart Circ Physiol, August 1, 2008; 295(2): H728 - H735. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y Takei, H Hashimoto, K Inoue, T Osaki, K Yoshizawa-Kumagaye, M Tsunemi, T X Watanabe, M Ogoshi, N Minamino, and Y Ueta Central and peripheral cardiovascular actions of adrenomedullin 5, a novel member of the calcitonin gene-related peptide family, in mammals J. Endocrinol., May 1, 2008; 197(2): 391 - 400. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Nobata, M. Ogoshi, and Y. Takei Potent cardiovascular actions of homologous adrenomedullins in eels Am J Physiol Regulatory Integrative Comp Physiol, May 1, 2008; 294(5): R1544 - R1553. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 F. Wunder, A. Rebmann, A. Geerts, and B. Kalthof Pharmacological and Kinetic Characterization of Adrenomedullin 1 and Calcitonin Gene-Related Peptide 1 Receptor Reporter Cell Lines Mol. Pharmacol., April 1, 2008; 73(4): 1235 - 1243. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y.-F. Chan, W.-S. O, and F. Tang Adrenomedullin in the Rat Testis. I: Its Production, Actions on Testosterone Secretion, Regulation by Human Chorionic Gonadotropin, and Its Interaction with Endothelin 1 in the Leydig Cell Biol Reprod, April 1, 2008; 78(4): 773 - 779. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Starr, R. Graepel, J. Keeble, S. Schmidhuber, N. Clark, A. Grant, A. M. Shah, and S. D. Brain A reactive oxygen species-mediated component in neurogenic vasodilatation Cardiovasc Res, April 1, 2008; 78(1): 139 - 147. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. G. R. De Mey, R. Megens, and G. E. Fazzi Functional Antagonism between Endogenous Neuropeptide Y and Calcitonin Gene-Related Peptide in Mesenteric Resistance Arteries J. Pharmacol. Exp. Ther., March 1, 2008; 324(3): 930 - 937. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Huang, A. Karve, I. Shah, M. C. Bowers, D. J. DiPette, S. C. Supowit, and G. S. Abela Deletion of the mouse {alpha}-calcitonin gene-related peptide gene increases the vulnerability of the heart to ischemia-reperfusion injury Am J Physiol Heart Circ Physiol, March 1, 2008; 294(3): H1291 - H1297. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K.-Y. Park and A. F. Russo Control of the Calcitonin Gene-related Peptide Enhancer by Upstream Stimulatory Factor in Trigeminal Ganglion Neurons J. Biol. Chem., February 29, 2008; 283(9): 5441 - 5451. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. N. Danaher, K. M. Loomes, B. L. Leonard, L. Whiting, D. L. Hay, L. Y. Xu, E. W. Kraegen, A. R. J. Phillips, and G. J. S. Cooper Evidence that {alpha}-Calcitonin Gene-Related Peptide Is a Neurohormone that Controls Systemic Lipid Availability and Utilization Endocrinology, January 1, 2008; 149(1): 154 - 160. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 B. E. Padilla, G. S. Cottrell, D. Roosterman, S. Pikios, L. Muller, M. Steinhoff, and N. W. Bunnett Endothelin-converting enzyme-1 regulates endosomal sorting of calcitonin receptor-like receptor and -arrestins J. Cell Biol., December 3, 2007; 179(5): 981 - 997. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. Hasdemir, N. W. Bunnett, and G. S. Cottrell Hepatocyte Growth Factor-regulated Tyrosine Kinase Substrate (HRS) Mediates Post-endocytic Trafficking of Protease-activated Receptor 2 and Calcitonin Receptor-like Receptor J. Biol. Chem., October 5, 2007; 282(40): 29646 - 29657. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 N. C. Gonzalez, J. Allen, V. G. Blanco, E. J. Schmidt, N. van Rooijen, and J. G. Wood Alveolar macrophages are necessary for the systemic inflammation of acute alveolar hypoxia J Appl Physiol, October 1, 2007; 103(4): 1386 - 1394. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. H. Kunz, M. Scott, L. M. Ittner, J. A. Fischer, W. Born, and J. Vogel Calcitonin gene-related peptide-evoked sustained tachycardia in calcitonin receptor-like receptor transgenic mice is mediated by sympathetic activity Am J Physiol Heart Circ Physiol, October 1, 2007; 293(4): H2155 - H2160. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. Zhong and D. H. Wang TRPV1 gene knockout impairs preconditioning protection against myocardial injury in isolated perfused hearts in mice Am J Physiol Heart Circ Physiol, September 1, 2007; 293(3): H1791 - H1798. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. C. Lim, N. G. Morgenthaler, T. Subramaniam, Y. S. Wu, S. K. Goh, and C. F. Sum The Relationship Between Adrenomedullin, Metabolic Factors, and Vascular Function in Individuals With Type 2 Diabetes Diabetes Care, June 1, 2007; 30(6): 1513 - 1519. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. S. Cottrell, B. Padilla, S. Pikios, D. Roosterman, M. Steinhoff, E. F. Grady, and N. W. Bunnett Post-endocytic Sorting of Calcitonin Receptor-like Receptor and Receptor Activity-modifying Protein 1 J. Biol. Chem., April 20, 2007; 282(16): 12260 - 12271. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. Gibbons, R. Dackor, W. Dunworth, K. Fritz-Six, and K. M. Caron Receptor Activity-Modifying Proteins: RAMPing up Adrenomedullin Signaling Mol. Endocrinol., April 1, 2007; 21(4): 783 - 796. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Dschietzig, C. Richter, L. Asswad, G. Baumann, and K. Stangl Hypoxic Induction of Receptor Activity-Modifying Protein 2 Alters Regulation of Pulmonary Endothelin-1 by Adrenomedullin: Induction under Normoxia Versus Inhibition under Hypoxia J. Pharmacol. Exp. Ther., April 1, 2007; 321(1): 409 - 419. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Z. Zhang, C. S. Winborn, B. Marquez de Prado, and A. F. Russo Sensitization of Calcitonin Gene-Related Peptide Receptors by Receptor Activity-Modifying Protein-1 in the Trigeminal Ganglion J. Neurosci., March 7, 2007; 27(10): 2693 - 2703. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. Caron, J. Hagaman, T. Nishikimi, H.-S. Kim, and O. Smithies Adrenomedullin gene expression differences in mice do not affect blood pressure but modulate hypertension-induced pathology in males PNAS, February 27, 2007; 104(9): 3420 - 3425. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. L. Favaloro and B. K. Kemp-Harper The nitroxyl anion (HNO) is a potent dilator of rat coronary vasculature Cardiovasc Res, February 1, 2007; 73(3): 587 - 596. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. L. Hay, G. Christopoulos, A. Christopoulos, and P. M. Sexton Mol. Pharmacol., December 1, 2006; 70(6): 1984 - 1991. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
W. Ma, J.-G. Chabot, and R. Quirion A role for adrenomedullin as a pain-related peptide in the rat PNAS, October 24, 2006; 103(43): 16027 - 16032. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. Roosterman, T. Goerge, S. W. Schneider, N. W. Bunnett, and M. Steinhoff Neuronal control of skin function: the skin as a neuroimmunoendocrine organ. Physiol Rev, October 1, 2006; 86(4): 1309 - 1379. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S Hagner, U Stahl, T Grimm, M Sturzl, and R E Lang Expression of calcitonin receptor-like receptor in human vascular tumours. J. Clin. Pathol., October 1, 2006; 59(10): 1104 - 1107. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. Dong, M. M. Taylor, W. K. Samson, and J. Ren Intermedin (adrenomedullin-2) enhances cardiac contractile function via a protein kinase C- and protein kinase A-dependent pathway in murine ventricular myocytes J Appl Physiol, September 1, 2006; 101(3): 778 - 784. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. R. Ross and C. Yallampalli Endothelium-Independent Relaxation by Adrenomedullin in Pregnant Rat Mesenteric Artery: Role of cAMP-Dependent Protein Kinase A and Calcium-Activated Potassium Channels J. Pharmacol. Exp. Ther., June 1, 2006; 317(3): 1269 - 1275. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Z. Zhang, I. M. Dickerson, and A. F. Russo Calcitonin Gene-Related Peptide Receptor Activation by Receptor Activity-Modifying Protein-1 Gene Transfer to Vascular Smooth Muscle Cells Endocrinology, April 1, 2006; 147(4): 1932 - 1940. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. L. Nikitenko, N. Blucher, S. B. Fox, R. Bicknell, D. M. Smith, and M. C. P. Rees Adrenomedullin and CGRP interact with endogenous calcitonin-receptor-like receptor in endothelial cells and induce its desensitisation by different mechanisms. J. Cell Sci., March 1, 2006; 119(Pt 5): 910 - 922. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C.W. Tam, K. Husmann, N.C. Clark, J.E. Clark, Z. Lazar, L.M. Ittner, J. Gotz, G. Douglas, A.D. Grant, D. Sugden, et al. Enhanced Vascular Responses to Adrenomedullin in Mice Overexpressing Receptor-Activity-Modifying Protein 2 Circ. Res., February 3, 2006; 98(2): 262 - 270. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Nag, A. Kato, T. Nakada, K. Hoshijima, A. C. Mistry, Y. Takei, and S. Hirose Molecular and functional characterization of adrenomedullin receptors in pufferfish Am J Physiol Regulatory Integrative Comp Physiol, February 1, 2006; 290(2): R467 - R478. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. R. Ross, M. Chauhan, P. R. Gangula, L. Reed, C. Thota, and C. Yallampalli Female Sex Steroids Increase Adrenomedullin-Induced Vasodilation by Increasing the Expression of Adrenomedullin2 Receptor Components in Rat Mesenteric Artery Endocrinology, January 1, 2006; 147(1): 389 - 396. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A.S. Thakor and D.A. Giussani Role of Nitric Oxide in Mediating In Vivo Vascular Responses to Calcitonin Gene-Related Peptide in Essential and Peripheral Circulations in the Fetus Circulation, October 18, 2005; 112(16): 2510 - 2516. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. C. Supowit, R. T. Ethridge, H. Zhao, K. A. Katki, and D. J. DiPette Calcitonin gene-related peptide and substance P contribute to reduced blood pressure in sympathectomized rats Am J Physiol Heart Circ Physiol, September 1, 2005; 289(3): H1169 - H1175. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. S Thakor, M. R Bloomfield, M Patterson, and D. A Giussani Calcitonin gene-related peptide antagonism attenuates the haemodynamic and glycaemic responses to acute hypoxaemia in the late gestation sheep fetus J. Physiol., July 15, 2005; 566(2): 587 - 597. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. M. Bomberger, W. S. Spielman, C. S. Hall, E. J. Weinman, and N. Parameswaran Receptor Activity-modifying Protein (RAMP) Isoform-specific Regulation of Adrenomedullin Receptor Trafficking by NHERF-1 J. Biol. Chem., June 24, 2005; 280(25): 23926 - 23935. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. Linscheid, D. Seboek, H. Zulewski, U. Keller, and B. Muller Autocrine/Paracrine Role of Inflammation-Mediated Calcitonin Gene-Related Peptide and Adrenomedullin Expression in Human Adipose Tissue Endocrinology, June 1, 2005; 146(6): 2699 - 2708. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. L. Hay, G. Christopoulos, A. Christopoulos, D. R. Poyner, and P. M. Sexton Pharmacological Discrimination of Calcitonin Receptor: Receptor Activity-Modifying Protein Complexes Mol. Pharmacol., May 1, 2005; 67(5): 1655 - 1665. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. Boussery, C. Delaey, and J. Van de Voorde The Vasorelaxing Effect of CGRP and Natriuretic Peptides in Isolated Bovine Retinal Arteries Invest. Ophthalmol. Vis. Sci., April 1, 2005; 46(4): 1420 - 1427. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. M. Taylor, S. L. Bagley, and W. K. Samson Intermedin/adrenomedullin-2 acts within central nervous system to elevate blood pressure and inhibit food and water intake Am J Physiol Regulatory Integrative Comp Physiol, April 1, 2005; 288(4): R919 - R927. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Katori, D. B. Hoover, J. L. Ardell, R. H. Helm, D. F. Belardi, C. G. Tocchetti, P. R. Forfia, D. A. Kass, and N. Paolocci Calcitonin Gene-Related Peptide In Vivo Positive Inotropy Is Attributable to Regional Sympatho-Stimulation and Is Blunted in Congestive Heart Failure Circ. Res., February 4, 2005; 96(2): 234 - 243. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| Visit Other APS Journals Online |
