Physiol Rev AJP: Heart and Circulatory Physiology
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Physiol. Rev. 85: 757-810, 2005; doi:10.1152/physrev.00057.2003
0031-9333/05 $18.00
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via ISI Web of Science (365)
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Parekh, A. B.
Right arrow Articles by Putney, J. W.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Parekh, A. B.
Right arrow Articles by Putney, J. W., Jr.

Store-Operated Calcium Channels

Anant B. Parekh and James W. Putney, Jr.

Department of Physiology, University of Oxford, Oxford, United Kingdom; and National Institute of Environmental Health Sciences-NIH, Research Triangle Park, North Carolina

In electrically nonexcitable cells, Ca2+ influx is essential for regulating a host of kinetically distinct processes involving exocytosis, enzyme control, gene regulation, cell growth and proliferation, and apoptosis. The major Ca2+ entry pathway in these cells is the store-operated one, in which the emptying of intracellular Ca2+ stores activates Ca2+ influx (store-operated Ca2+ entry, or capacitative Ca2+ entry). Several biophysically distinct store-operated currents have been reported, but the best characterized is the Ca2+ release-activated Ca2+ current, ICRAC. Although it was initially considered to function only in nonexcitable cells, growing evidence now points towards a central role for ICRAC-like currents in excitable cells too. In spite of intense research, the signal that relays the store Ca2+ content to CRAC channels in the plasma membrane, as well as the molecular identity of the Ca2+ sensor within the stores, remains elusive. Resolution of these issues would be greatly helped by the identification of the CRAC channel gene. In some systems, evidence suggests that store-operated channels might be related to TRP homologs, although no consensus has yet been reached. Better understood are mechanisms that inactivate store-operated entry and hence control the overall duration of Ca2+ entry. Recent work has revealed a central role for mitochondria in the regulation of ICRAC, and this is particularly prominent under physiological conditions. ICRAC therefore represents a dynamic interplay between endoplasmic reticulum, mitochondria, and plasma membrane. In this review, we describe the key electrophysiological features of ICRAC and other store-operated Ca2+ currents and how they are regulated, and we consider recent advances that have shed insight into the molecular mechanisms involved in this ubiquitous and vital Ca2+ entry pathway.




This article has been cited by other articles:


Home page
 J. Biol. Chem.Home page
A. M. Bair, P. B. Thippegowda, M. Freichel, N. Cheng, R. D. Ye, S. M. Vogel, Y. Yu, V. Flockerzi, A. B. Malik, and C. Tiruppathi
Ca2+ Entry via TRPC Channels Is Necessary for Thrombin-induced NF-{kappa}B Activation in Endothelial Cells through AMP-activated Protein Kinase and Protein Kinase C{delta}
J. Biol. Chem., January 2, 2009; 284(1): 563 - 574.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Cell Physiol.Home page
J. N. Rao, S. V. Liu, T. Zou, L. Liu, L. Xiao, X. Zhang, E. Bellavance, J. X.-J. Yuan, and J.-Y. Wang
Rac1 promotes intestinal epithelial restitution by increasing Ca2+ influx through interaction with phospholipase C-{gamma}1 after wounding
Am J Physiol Cell Physiol, December 1, 2008; 295(6): C1499 - C1509.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
F.-X. Boittin, F. Gribi, K. Serir, and J.-L. Beny
Ca2+-independent PLA2 controls endothelial store-operated Ca2+ entry and vascular tone in intact aorta
Am J Physiol Heart Circ Physiol, December 1, 2008; 295(6): H2466 - H2474.
[Abstract] [Full Text] [PDF]

Home page
 Circ. Res.Home page
I. F. Abdullaev, J. M. Bisaillon, M. Potier, J. C. Gonzalez, R. K. Motiani, and M. Trebak
Stim1 and Orai1 Mediate CRAC Currents and Store-Operated Calcium Entry Important for Endothelial Cell Proliferation
Circ. Res., November 21, 2008; 103(11): 1289 - 1299.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
N. Matzner, I. M. Zemtsova, N. T. Xuan, M. Duszenko, E. Shumilina, and F. Lang
Ion Channels Modulating Mouse Dendritic Cell Functions
J. Immunol., November 15, 2008; 181(10): 6803 - 6809.
[Abstract] [Full Text] [PDF]

Home page
 J. Physiol.Home page
L. Navarro-Borelly, A. Somasundaram, M. Yamashita, D. Ren, R. J. Miller, and M. Prakriya
STIM1-Orai1 interactions and Orai1 conformational changes revealed by live-cell FRET microscopy
J. Physiol., November 15, 2008; 586(22): 5383 - 5401.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
S. W. Ng, J. di Capite, K. Singaravelu, and A. B. Parekh
Sustained Activation of the Tyrosine Kinase Syk by Antigen in Mast Cells Requires Local Ca2+ Influx through Ca2+ Release-activated Ca2+ Channels
J. Biol. Chem., November 14, 2008; 283(46): 31348 - 31355.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Cell Physiol.Home page
T. Gwozdz, J. Dutko-Gwozdz, V. Zarayskiy, K. Peter, and V. M. Bolotina
How strict is the correlation between STIM1 and Orai1 expression, puncta formation, and ICRAC activation?
Am J Physiol Cell Physiol, November 1, 2008; 295(5): C1133 - C1140.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
K. Nakata, T. Yoshimaru, Y. Suzuki, T. Inoue, C. Ra, H. Yakura, and K. Mizuno
Positive and Negative Regulation of High Affinity IgE Receptor Signaling by Src Homology Region 2 Domain-Containing Phosphatase 1
J. Immunol., October 15, 2008; 181(8): 5414 - 5424.
[Abstract] [Full Text] [PDF]

Home page
 J. Physiol.Home page
T. Szikra, K. Cusato, W. B. Thoreson, P. Barabas, T. M. Bartoletti, and D. Krizaj
Depletion of calcium stores regulates calcium influx and signal transmission in rod photoreceptors
J. Physiol., October 15, 2008; 586(20): 4859 - 4875.
[Abstract] [Full Text] [PDF]

Home page
 J. Physiol.Home page
A. D. Lyfenko and R. T. Dirksen
Differential dependence of store-operated and excitation-coupled Ca2+ entry in skeletal muscle on STIM1 and Orai1
J. Physiol., October 15, 2008; 586(20): 4815 - 4824.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
S. Bezin, G. Charpentier, H. C. Lee, G. Baux, P. Fossier, and J.-M. Cancela
Regulation of Nuclear Ca2+ Signaling by Translocation of the Ca2+ Messenger Synthesizing Enzyme ADP-ribosyl Cyclase during Neuronal Depolarization
J. Biol. Chem., October 10, 2008; 283(41): 27859 - 27870.
[Abstract] [Full Text] [PDF]

Home page
 J. Cell Sci.Home page
R. Malli, S. Naghdi, C. Romanin, and W. F. Graier
Cytosolic Ca2+ prevents the subplasmalemmal clustering of STIM1: an intrinsic mechanism to avoid Ca2+ overload
J. Cell Sci., October 1, 2008; 121(19): 3133 - 3139.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
T. Hewavitharana, X. Deng, Y. Wang, M. F. Ritchie, G. V. Girish, J. Soboloff, and D. L. Gill
Location and Function of STIM1 in the Activation of Ca2+ Entry Signals
J. Biol. Chem., September 19, 2008; 283(38): 26252 - 26262.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
I. Jardin, J. J. Lopez, G. M. Salido, and J. A. Rosado
Orai1 Mediates the Interaction between STIM1 and hTRPC1 and Regulates the Mode of Activation of hTRPC1-forming Ca2+ Channels
J. Biol. Chem., September 12, 2008; 283(37): 25296 - 25304.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Cell Physiol.Home page
R. Berra-Romani, A. Mazzocco-Spezzia, M. V. Pulina, and V. A. Golovina
Ca2+ handling is altered when arterial myocytes progress from a contractile to a proliferative phenotype in culture
Am J Physiol Cell Physiol, September 1, 2008; 295(3): C779 - C790.
[Abstract] [Full Text] [PDF]

Home page
 J Biomol ScreenHome page
R. L. Schroder, S. Friis, M. Sunesen, C. Mathes, and N. J. Willumsen
Automated Patch-Clamp Technique: Increased Throughput in Functional Characterization and in Pharmacological Screening of Small-Conductance Ca2+ Release-Activated Ca2+ Channels
J Biomol Screen, August 1, 2008; 13(7): 638 - 647.
[Abstract] [PDF]

Home page
 CarcinogenesisHome page
S. Fedida-Metula, S. Elhyany, S. Tsory, S. Segal, M. Hershfinkel, I. Sekler, and D. Fishman
Targeting lipid rafts inhibits protein kinase B by disrupting calcium homeostasis and attenuates malignant properties of melanoma cells
Carcinogenesis, August 1, 2008; 29(8): 1546 - 1554.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
W. I. DeHaven, J. T. Smyth, R. R. Boyles, G. S. Bird, and J. W. Putney Jr.
Complex Actions of 2-Aminoethyldiphenyl Borate on Store-operated Calcium Entry
J. Biol. Chem., July 11, 2008; 283(28): 19265 - 19273.
[Abstract] [Full Text] [PDF]

Home page
 J. Physiol.Home page
A. B. Parekh
Store-operated channels: mechanisms and function
J. Physiol., July 1, 2008; 586(13): 3033 - 3033.
[Full Text] [PDF]

Home page
 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
W. Lu, J. Wang, L. A. Shimoda, and J. T. Sylvester
Differences in STIM1 and TRPC expression in proximal and distal pulmonary arterial smooth muscle are associated with differences in Ca2+ responses to hypoxia
Am J Physiol Lung Cell Mol Physiol, July 1, 2008; 295(1): L104 - L113.
[Abstract] [Full Text] [PDF]

Home page
 J. Physiol.Home page
J. W. Putney and G. S. Bird
Cytoplasmic calcium oscillations and store-operated calcium influx
J. Physiol., July 1, 2008; 586(13): 3055 - 3059.
[Abstract] [Full Text] [PDF]

Home page
 J. Physiol.Home page
A. B. Parekh
Ca2+ microdomains near plasma membrane Ca2+ channels: impact on cell function
J. Physiol., July 1, 2008; 586(13): 3043 - 3054.
[Abstract] [Full Text] [PDF]

Home page
 J. Physiol.Home page
V. M. Bolotina
Orai, STIM1 and iPLA2{beta}: a view from a different perspective
J. Physiol., July 1, 2008; 586(13): 3035 - 3042.
[Abstract] [Full Text] [PDF]

Home page
 Mol Biol EvolHome page
X. Cai
Unicellular Ca2+ Signaling 'Toolkit' at the Origin of Metazoa
Mol. Biol. Evol., July 1, 2008; 25(7): 1357 - 1361.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
S. L. Zhang, J. A. Kozak, W. Jiang, A. V. Yeromin, J. Chen, Y. Yu, A. Penna, W. Shen, V. Chi, and M. D. Cahalan
Store-dependent and -independent Modes Regulating Ca2+ Release-activated Ca2+ Channel Activity of Human Orai1 and Orai3
J. Biol. Chem., June 20, 2008; 283(25): 17662 - 17671.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
B. Pani, H. L. Ong, X. Liu, K. Rauser, I. S. Ambudkar, and B. B. Singh
Lipid Rafts Determine Clustering of STIM1 in Endoplasmic Reticulum-Plasma Membrane Junctions and Regulation of Store-operated Ca2+ Entry (SOCE)
J. Biol. Chem., June 20, 2008; 283(25): 17333 - 17340.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Cell Physiol.Home page
G. E. Woodard, G. M. Salido, and J. A. Rosado
Enhanced exocytotic-like insertion of Orai1 into the plasma membrane upon intracellular Ca2+ store depletion
Am J Physiol Cell Physiol, June 1, 2008; 294(6): C1323 - C1331.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Cell Physiol.Home page
T. Smani, T. Patel, and V. M. Bolotina
Complex regulation of store-operated Ca2+ entry pathway by PKC-{varepsilon} in vascular SMCs
Am J Physiol Cell Physiol, June 1, 2008; 294(6): C1499 - C1508.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
M. A. Spassova, T. Hewavitharana, R. A. Fandino, A. Kaya, J. Tanaka, and D. L. Gill
Voltage Gating at the Selectivity Filter of the Ca2+ Release-activated Ca2+ Channel Induced by Mutation of the Orai1 Protein
J. Biol. Chem., May 30, 2008; 283(22): 14938 - 14945.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
P. Csutora, K. Peter, H. Kilic, K. M. Park, V. Zarayskiy, T. Gwozdz, and V. M. Bolotina
Novel Role for STIM1 as a Trigger for Calcium Influx Factor Production
J. Biol. Chem., May 23, 2008; 283(21): 14524 - 14531.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
A. El-Yassimi, A. Hichami, P. Besnard, and N. A. Khan
Linoleic Acid Induces Calcium Signaling, Src Kinase Phosphorylation, and Neurotransmitter Release in Mouse CD36-positive Gustatory Cells
J. Biol. Chem., May 9, 2008; 283(19): 12949 - 12959.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
K. T. Cheng, X. Liu, H. L. Ong, and I. S. Ambudkar
Functional Requirement for Orai1 in Store-operated TRPC1-STIM1 Channels
J. Biol. Chem., May 9, 2008; 283(19): 12935 - 12940.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
S. Dadsetan, L. Zakharova, T. F. Molinski, and A. F. Fomina
Store-operated Ca2+ Influx Causes Ca2+ Release from the Intracellular Ca2+ Channels That Is Required for T Cell Activation
J. Biol. Chem., May 2, 2008; 283(18): 12512 - 12519.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
D. Smrz, P. Lebduska, L. Draberova, J. Korb, and P. Draber
Engagement of Phospholipid Scramblase 1 in Activated Cells: IMPLICATION FOR PHOSPHATIDYLSERINE EXTERNALIZATION AND EXOCYTOSIS
J. Biol. Chem., April 18, 2008; 283(16): 10904 - 10918.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
M. Muik, I. Frischauf, I. Derler, M. Fahrner, J. Bergsmann, P. Eder, R. Schindl, C. Hesch, B. Polzinger, R. Fritsch, et al.
Dynamic Coupling of the Putative Coiled-coil Domain of ORAI1 with STIM1 Mediates ORAI1 Channel Activation
J. Biol. Chem., March 21, 2008; 283(12): 8014 - 8022.
[Abstract] [Full Text] [PDF]

Home page
 J. Cell Sci.Home page
J. T. Smyth, W. I. DeHaven, G. S. Bird, and J. W. Putney Jr
Ca2+-store-dependent and -independent reversal of Stim1 localization and function
J. Cell Sci., March 15, 2008; 121(6): 762 - 772.
[Abstract] [Full Text] [PDF]

Home page
 FASEB J.Home page
S. Parvez, A. Beck, C. Peinelt, J. Soboloff, A. Lis, M. Monteilh-Zoller, Donald. L. Gill, A. Fleig, and R. Penner
STIM2 protein mediates distinct store-dependent and store-independent modes of CRAC channel activation
FASEB J, March 1, 2008; 22(3): 752 - 761.
[Abstract] [Full Text] [PDF]

Home page
 CirculationHome page
J. Saliez, C. Bouzin, G. Rath, P. Ghisdal, F. Desjardins, R. Rezzani, L.F. Rodella, J. Vriens, B. Nilius, O. Feron, et al.
Role of Caveolar Compartmentation in Endothelium-Derived Hyperpolarizing Factor-Mediated Relaxation: Ca2+ Signals and Gap Junction Function Are Regulated by Caveolin in Endothelial Cells
Circulation, February 26, 2008; 117(8): 1065 - 1074.
[Abstract] [Full Text] [PDF]

Home page
 JGPHome page
J. Xing, X. Yan, A. Estevez, and K. Strange
Highly Ca2+-selective TRPM Channels Regulate IP3-dependent Oscillatory Ca2+ Signaling in the C. elegans Intestine
J. Gen. Physiol., February 25, 2008; 131(3): 245 - 255.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
W.-C. Chang, J. Di Capite, K. Singaravelu, C. Nelson, V. Halse, and A. B. Parekh
Local Ca2+ Influx through Ca2+ Release-activated Ca2+ (CRAC) Channels Stimulates Production of an Intracellular Messenger and an Intercellular Pro-inflammatory Signal
J. Biol. Chem., February 22, 2008; 283(8): 4622 - 4631.
[Abstract] [Full Text] [PDF]

Home page
 IOVSHome page
E. Abad, G. Lorente, N. Gavara, M. Morales, A. Gual, and X. Gasull
Activation of Store-Operated Ca2+ Channels in Trabecular Meshwork Cells
Invest. Ophthalmol. Vis. Sci., February 1, 2008; 49(2): 677 - 686.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
G. C. Sieck, T. A. White, M. A. Thompson, C. M. Pabelick, M. E. Wylam, and Y. S. Prakash
Regulation of store-operated Ca2+ entry by CD38 in human airway smooth muscle
Am J Physiol Lung Cell Mol Physiol, February 1, 2008; 294(2): L378 - L385.
[Abstract] [Full Text] [PDF]

Home page
 Biol. Reprod.Home page
F. J. Martin-Romero, J. R. Ortiz-de-Galisteo, J. Lara-Laranjeira, J. A. Dominguez-Arroyo, E. Gonzalez-Carrera, and I. S Alvarez
Store-Operated Calcium Entry in Human Oocytes and Sensitivity to Oxidative Stress
Biol Reprod, February 1, 2008; 78(2): 307 - 315.
[Abstract] [Full Text] [PDF]

Home page
 J. Physiol.Home page
S. Borges, S. Lindstrom, C. Walters, A. Warrier, and M. Wilson
Discrete influx events refill depleted Ca2+ stores in a chick retinal neuron
J. Physiol., January 15, 2008; 586(2): 605 - 626.
[Abstract] [Full Text] [PDF]

Home page
 Proc Am Thorac SocHome page
M. J. Sanderson, P. Delmotte, Y. Bai, and J. F. Perez-Zogbhi
Regulation of Airway Smooth Muscle Cell Contractility by Ca2+ Signaling and Sensitivity
Proceedings of the ATS, January 1, 2008; 5(1): 23 - 31.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Cell Physiol.Home page
L. C. Ng, B. D. Kyle, A. R. Lennox, X.-M. Shen, W. J. Hatton, and J. R. Hume
Cell culture alters Ca2+ entry pathways activated by store-depletion or hypoxia in canine pulmonary arterial smooth muscle cells
Am J Physiol Cell Physiol, January 1, 2008; 294(1): C313 - C323.
[Abstract] [Full Text] [PDF]

Home page
 J. Physiol.Home page
O. Mignen, J. L. Thompson, and T. J. Shuttleworth
Both Orai1 and Orai3 are essential components of the arachidonate-regulated Ca2+-selective (ARC) channels
J. Physiol., January 1, 2008; 586(1): 185 - 195.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
L. Andresen, H. Jensen, M. T. Pedersen, K. A. Hansen, and S. Skov
Molecular Regulation of MHC Class I Chain-Related Protein A Expression after HDAC-Inhibitor Treatment of Jurkat T Cells
J. Immunol., December 15, 2007; 179(12): 8235 - 8242.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
R. A. Nichols, A. F. Dengler, E. M. Nakagawa, M. Bashkin, B. T. Paul, J. Wu, and G. M. Khan
A Constitutive, Transient Receptor Potential-like Ca2+ Influx Pathway in Presynaptic Nerve Endings Independent of Voltage-gated Ca2+ Channels and Na+/Ca2+ Exchange
J. Biol. Chem., December 7, 2007; 282(49): 36102 - 36111.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
S. Wu, H. Chen, M. F. Alexeyev, J. A. C. King, T. M. Moore, T. Stevens, and R. D. Balczon
Microtubule Motors Regulate ISOC Activation Necessary to Increase Endothelial Cell Permeability
J. Biol. Chem., November 30, 2007; 282(48): 34801 - 34808.
[Abstract] [Full Text] [PDF]

Home page
 Circ. Res.Home page
T. Smani, A. Dominguez-Rodriguez, A. Hmadcha, E. Calderon-Sanchez, A. Horrillo-Ledesma, and A. Ordonez
Role of Ca2+-Independent Phospholipase A2 and Store-Operated Pathway in Urocortin-Induced Vasodilatation of Rat Coronary Artery
Circ. Res., November 26, 2007; 101(11): 1194 - 1203.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
M. T. Khan, C. D. Bhanumathy, Z. T. Schug, and S. K. Joseph
Role of Inositol 1,4,5-Trisphosphate Receptors in Apoptosis in DT40 Lymphocytes
J. Biol. Chem., November 9, 2007; 282(45): 32983 - 32990.
[Abstract] [Full Text] [PDF]

Home page
 Circ. Res.Home page
D. Poburko, C.-H. Liao, V. S. Lemos, E. Lin, Y. Maruyama, W. C. Cole, and C. van Breemen
Transient Receptor Potential Channel 6 Mediated, Localized Cytosolic [Na+] Transients Drive Na+/Ca2+ Exchanger Mediated Ca2+ Entry in Purinergically Stimulated Aorta Smooth Muscle Cells
Circ. Res., November 9, 2007; 101(10): 1030 - 1038.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Cell. Biol.Home page
B. J. Hawkins, L. A. Solt, I. Chowdhury, A. S. Kazi, M. R. Abid, W. C. Aird, M. J. May, J. K. Foskett, and M. Madesh
G Protein-Coupled Receptor Ca2+-Linked Mitochondrial Reactive Oxygen Species Are Essential for Endothelial/Leukocyte Adherence
Mol. Cell. Biol., November 1, 2007; 27(21): 7582 - 7593.
[Abstract] [Full Text] [PDF]

Home page
 J. Leukoc. Biol.Home page
A. J. Sandoval, J. P. Riquelme, M. D. Carretta, J. L. Hancke, M. A. Hidalgo, and R. A. Burgos
Store-operated calcium entry mediates intracellular alkalinization, ERK1/2, and Akt/PKB phosphorylation in bovine neutrophils
J. Leukoc. Biol., November 1, 2007; 82(5): 1266 - 1277.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Gastrointest. Liver Physiol.Home page
S. S. N. Kolar, R. Barhoumi, E. S. Callaway, Y.-Y. Fan, N. Wang, J. R. Lupton, and R. S. Chapkin
Synergy between docosahexaenoic acid and butyrate elicits p53-independent apoptosis via mitochondrial Ca2+ accumulation in colonocytes
Am J Physiol Gastrointest Liver Physiol, November 1, 2007; 293(5): G935 - G943.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
Y. S. Prakash, M. A. Thompson, B. Vaa, I. Matabdin, T. E. Peterson, T. He, and C. M. Pabelick
Caveolins and intracellular calcium regulation in human airway smooth muscle
Am J Physiol Lung Cell Mol Physiol, November 1, 2007; 293(5): L1118 - L1126.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Renal Physiol.Home page
M. Goel, W. G. Sinkins, C.-D. Zuo, U. Hopfer, and W. P. Schilling
Vasopressin-induced membrane trafficking of TRPC3 and AQP2 channels in cells of the rat renal collecting duct
Am J Physiol Renal Physiol, November 1, 2007; 293(5): F1476 - F1488.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
X. Liu, K. T. Cheng, B. C. Bandyopadhyay, B. Pani, A. Dietrich, B. C. Paria, W. D. Swaim, D. Beech, E. Yildrim, B. B. Singh, et al.
Attenuation of store-operate