| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
Department of Biosciences and Nutrition, Karolinska Institutet, Huddinge, Sweden; Structural Genomics Consortium, Botnar Research Centre, University of Oxford, Headington, Oxford, United Kingdom; and Department of Pharmacology, University of Toronto, Toronto, Ontario, Canada
During the past decade there has been a substantial advance in our understanding of estrogen signaling both from a clinical as well as a preclinical perspective. Estrogen signaling is a balance between two opposing forces in the form of two distinct receptors (ER
and ER
) and their splice variants. The prospect that these two pathways can be selectively stimulated or inhibited with subtype-selective drugs constitutes new and promising therapeutic opportunities in clinical areas as diverse as hormone replacement, autoimmune diseases, prostate and breast cancer, and depression. Molecular biological, biochemical, and structural studies have generated information which is invaluable for the development of more selective and effective ER ligands. We have also become aware that ERs do not function by themselves but require a number of coregulatory proteins whose cell-specific expression explains some of the distinct cellular actions of estrogen. Estrogen is an important morphogen, and many of its proliferative effects on the epithelial compartment of glands are mediated by growth factors secreted from the stromal compartment. Thus understanding the cross-talk between growth factor and estrogen signaling is essential for understanding both normal and malignant growth. In this review we focus on several of the interesting recent discoveries concerning estrogen receptors, on estrogen as a morphogen, and on the molecular mechanisms of anti-estrogen signaling.
This article has been cited by other articles:
|
|
 |
|
  D. J Kojetin, T. P Burris, E. V Jensen, and S. A Khan Implications of the binding of tamoxifen to the coactivator recognition site of the estrogen receptor Endocr. Relat. Cancer, December 1, 2008; 15(4): 851 - 870. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S.-H. Chung, K. Wiedmeyer, A. Shai, K. S. Korach, and P. F. Lambert Requirement for Estrogen Receptor {alpha} in a Mouse Model for Human Papillomavirus-Associated Cervical Cancer Cancer Res., December 1, 2008; 68(23): 9928 - 9934. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y. F. Pan, K. D. S. A. Wansa, M. H. Liu, B. Zhao, S. Z. Hong, P. Y. Tan, K. S. Lim, G. Bourque, E. T. Liu, and E. Cheung Regulation of Estrogen Receptor-mediated Long Range Transcription via Evolutionarily Conserved Distal Response Elements J. Biol. Chem., November 21, 2008; 283(47): 32977 - 32988. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Xu, Y. Cheng, J. R. Keast, and P. B. Osborne 17{beta}-Estradiol Activates Estrogen Receptor {beta}-Signalling and Inhibits Transient Receptor Potential Vanilloid Receptor 1 Activation by Capsaicin in Adult Rat Nociceptor Neurons Endocrinology, November 1, 2008; 149(11): 5540 - 5548. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. Bittencourt, M. Dutertre, G. Sanchez, J. Barbier, L. Gratadou, and D. Auboeuf Cotranscriptional Splicing Potentiates the mRNA Production from a Subset of Estradiol-Stimulated Genes Mol. Cell. Biol., September 15, 2008; 28(18): 5811 - 5824. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. Ogba, L. J. Chaplin, Y. Q. Doughman, K. Fujinaga, and M. M. Montano HEXIM1 Regulates 17{beta}-Estradiol/Estrogen Receptor-{alpha}-Mediated Expression of Cyclin D1 in Mammary Cells via Modulation of P-TEFb Cancer Res., September 1, 2008; 68(17): 7015 - 7024. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 F. Yasuhara, G. R. O. Gomes, E. R. Siu, C. I. Suenaga, E. Marostica, C. S. Porto, and M. F. M. Lazari Effects of the Antiestrogen Fulvestrant (ICI 182,780) on Gene Expression of the Rat Efferent Ductules Biol Reprod, September 1, 2008; 79(3): 432 - 441. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Chakrabarty, A. Blacklock, S. Svojanovsky, and P. G. Smith Estrogen Elicits Dorsal Root Ganglion Axon Sprouting via a Renin-Angiotensin System Endocrinology, July 1, 2008; 149(7): 3452 - 3460. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 V. M. Miller and S. P. Duckles Vascular Actions of Estrogens: Functional Implications Pharmacol. Rev., June 1, 2008; 60(2): 210 - 241. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 V. Douin-Echinard, S. Laffont, C. Seillet, L. Delpy, A. Krust, P. Chambon, P. Gourdy, J.-F. Arnal, and J.-C. Guery Estrogen Receptor {alpha}, but Not {beta}, Is Required for Optimal Dendritic Cell Differentiation and CD40-Induced Cytokine Production J. Immunol., March 15, 2008; 180(6): 3661 - 3669. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J.-M. Renoir, C. Bouclier, A. Seguin, V. Marsaud, and B. Sola Antioestrogen-mediated cell cycle arrest and apoptosis induction in breast cancer and multiple myeloma cells J. Mol. Endocrinol., March 1, 2008; 40(3): 101 - 112. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y. Liu, H. Gao, T. T. Marstrand, A. Strom, E. Valen, A. Sandelin, J.-A. Gustafsson, and K. Dahlman-Wright The genome landscape of ER{alpha}- and ER{beta}-binding DNA regions PNAS, February 19, 2008; 105(7): 2604 - 2609. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 F. Stormshak and C. V. Bishop BOARD-INVITED REVIEW: Estrogen and progesterone signaling: Genomic and nongenomic actions in domestic ruminants J Anim Sci, February 1, 2008; 86(2): 299 - 315. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. P. Konhilas and L. A. Leinwand The Effects of Biological Sex and Diet on the Development of Heart Failure Circulation, December 4, 2007; 116(23): 2747 - 2759. [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| Visit Other APS Journals Online |
